Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox
One free-ranging Gray fox (<i>Urocyon cinereoargenteus</i>) underwent autopsy following neurologic disease, with findings including morbilliviral inclusions and associated lesions in numerous tissues, adenoviral intranuclear inclusions in bronchial epithelial cells, and septic pleuropneu...
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MDPI AG
2020-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/7/591 |
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| author | David B. Needle Jacqueline L. Marr Cooper J. Park Cheryl P. Andam Annabel G. Wise Roger K. Maes Rebecca P. Wilkes Eman A. Anis Inga F. Sidor Dalen Agnew Julie C. Ellis Patrick Tate Abigail Mathewson Christopher Benton Robert Gibson |
| author_facet | David B. Needle Jacqueline L. Marr Cooper J. Park Cheryl P. Andam Annabel G. Wise Roger K. Maes Rebecca P. Wilkes Eman A. Anis Inga F. Sidor Dalen Agnew Julie C. Ellis Patrick Tate Abigail Mathewson Christopher Benton Robert Gibson |
| author_sort | David B. Needle |
| collection | DOAJ |
| description | One free-ranging Gray fox (<i>Urocyon cinereoargenteus</i>) underwent autopsy following neurologic disease, with findings including morbilliviral inclusions and associated lesions in numerous tissues, adenoviral intranuclear inclusions in bronchial epithelial cells, and septic pleuropneumonia, hepatitis, splenitis, and meningoencephalitis. Molecular diagnostics on fresh lung identified a strain within a distinct clade of canine distemper that is currently unique to wildlife in New England, as well as the emerging multi-host viral pathogen skunk adenovirus-1. Bacterial culture of fresh liver resulted in a pure growth of <i>Listeria</i> <i>monocytogenes</i>, with whole genome sequencing indicating that the isolate had a vast array of antimicrobial resistance and virulence-associated genes. One year later, a second fox was euthanized for inappropriate behavior in a residential area, and diagnostic workup revealed canine distemper and septic <i>L. monocytogenes</i>, with the former closely related to the distemper virus found in the previous fox and the latter divergent from the <i>L. monocytogenes</i> from the previous fox. |
| first_indexed | 2024-03-10T18:19:34Z |
| format | Article |
| id | doaj.art-1f6c362bc3ad40b5bf0c9609e4ee3f6a |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T18:19:34Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-1f6c362bc3ad40b5bf0c9609e4ee3f6a2023-11-20T07:24:36ZengMDPI AGPathogens2076-08172020-07-019759110.3390/pathogens9070591Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray FoxDavid B. Needle0Jacqueline L. Marr1Cooper J. Park2Cheryl P. Andam3Annabel G. Wise4Roger K. Maes5Rebecca P. Wilkes6Eman A. Anis7Inga F. Sidor8Dalen Agnew9Julie C. Ellis10Patrick Tate11Abigail Mathewson12Christopher Benton13Robert Gibson14New Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH 03824, USAAnimal Health Diagnostic Center, Cornell University, Ithaca, NY 14850, USACollege of Life Sciences and Agriculture, University of New Hampshire, Durham, NH 03824, USACollege of Life Sciences and Agriculture, University of New Hampshire, Durham, NH 03824, USAVeterinary Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USAVeterinary Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USAAnimal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907, USAPennsylvania Animal Diagnostic Laboratory System, University of Pennsylvania, Philadelphia, PA 19104, USANew Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH 03824, USAVeterinary Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USANortheast Wildlife Disease Cooperative, University of Pennsylvania, Philadelphia, PA 19104, USANew Hampshire Fish and Game, Concord, NH 03301, USADivision of Public Health Services, New Hampshire Department of Health and Human Services, Concord, NH 03301, USADivision of Public Health Services, New Hampshire Department of Health and Human Services, Concord, NH 03301, USANew Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH 03824, USAOne free-ranging Gray fox (<i>Urocyon cinereoargenteus</i>) underwent autopsy following neurologic disease, with findings including morbilliviral inclusions and associated lesions in numerous tissues, adenoviral intranuclear inclusions in bronchial epithelial cells, and septic pleuropneumonia, hepatitis, splenitis, and meningoencephalitis. Molecular diagnostics on fresh lung identified a strain within a distinct clade of canine distemper that is currently unique to wildlife in New England, as well as the emerging multi-host viral pathogen skunk adenovirus-1. Bacterial culture of fresh liver resulted in a pure growth of <i>Listeria</i> <i>monocytogenes</i>, with whole genome sequencing indicating that the isolate had a vast array of antimicrobial resistance and virulence-associated genes. One year later, a second fox was euthanized for inappropriate behavior in a residential area, and diagnostic workup revealed canine distemper and septic <i>L. monocytogenes</i>, with the former closely related to the distemper virus found in the previous fox and the latter divergent from the <i>L. monocytogenes</i> from the previous fox.https://www.mdpi.com/2076-0817/9/7/591Gray foxcanine distemper virusadenovirusskunk adenovirus<i>Listeria</i>listeriosis |
| spellingShingle | David B. Needle Jacqueline L. Marr Cooper J. Park Cheryl P. Andam Annabel G. Wise Roger K. Maes Rebecca P. Wilkes Eman A. Anis Inga F. Sidor Dalen Agnew Julie C. Ellis Patrick Tate Abigail Mathewson Christopher Benton Robert Gibson Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox Pathogens Gray fox canine distemper virus adenovirus skunk adenovirus <i>Listeria</i> listeriosis |
| title | Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox |
| title_full | Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox |
| title_fullStr | Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox |
| title_full_unstemmed | Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox |
| title_short | Concurrent Infection of Skunk Adenovirus-1, <i>Listeria monocytogenes</i>, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (<i>Urocyon cinereoargenteus</i>) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox |
| title_sort | concurrent infection of skunk adenovirus 1 i listeria monocytogenes i and a regionally specific clade of canine distemper virus in one gray fox i urocyon cinereoargenteus i and concurrent listeriosis and canine distemper in a second gray fox |
| topic | Gray fox canine distemper virus adenovirus skunk adenovirus <i>Listeria</i> listeriosis |
| url | https://www.mdpi.com/2076-0817/9/7/591 |
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