TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.

TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.

TIPE2, the tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2), plays an essential role in maintaining immune homeostasis. It is highly expressed in macrophages and negatively regulates inflammation through inhibiting Toll-like receptor signaling. In this paper, we utilized RAW264...

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Bibliographic Details
Main Authors:	Yunwei Lou, Guizhong Zhang, Minghong Geng, Wenqian Zhang, Jian Cui, Suxia Liu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4013027?pdf=render

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