Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry
BackgroundThere are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis.MethodsWe analyzed 6,434 consecutive asymptomatic individuals without previous history of coronary artery disease who underwent coronary computed tomographic angiography (CCTA) (mea...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2020-06-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-44-470.pdf |
| _version_ | 1818446335672582144 |
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| author | Gyung-Min Park Chang Hoon Lee Seung-Whan Lee Sung-Cheol Yun Young-Hak Kim Yong-Giun Kim Ki-Bum Won Soe Hee Ann Shin-Jae Kim Dong Hyun Yang Joon-Won Kang Tae-Hwan Lim Eun Hee Koh Woo Je Lee Min-Seon Kim Joong-Yeol Park Hong-Kyu Kim Jaewon Choe Sang-Gon Lee |
| author_facet | Gyung-Min Park Chang Hoon Lee Seung-Whan Lee Sung-Cheol Yun Young-Hak Kim Yong-Giun Kim Ki-Bum Won Soe Hee Ann Shin-Jae Kim Dong Hyun Yang Joon-Won Kang Tae-Hwan Lim Eun Hee Koh Woo Je Lee Min-Seon Kim Joong-Yeol Park Hong-Kyu Kim Jaewon Choe Sang-Gon Lee |
| author_sort | Gyung-Min Park |
| collection | DOAJ |
| description | BackgroundThere are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis.MethodsWe analyzed 6,434 consecutive asymptomatic individuals without previous history of coronary artery disease who underwent coronary computed tomographic angiography (CCTA) (mean age, 53.7±7.6 years and 4,694 men [73.0%]). The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Study participants were categorized as normal (n=5,319), controlled diabetes (glycosylated hemoglobin [HbA1c] <7%, n=747), or uncontrolled diabetes (HbA1c ≥7%, n=368), respectively.ResultsCompared with normal individuals, there were no statistically significant differences in the risk of for any atherosclerotic plaque (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.98 to 1.38; P=0.086) and significant coronary artery stenosis (OR, 1.08; 95% CI, 0.82 to 1.42; P=0.583) in controlled diabetic individuals. In contrast, uncontrolled diabetic individuals had consistently higher risks of any atherosclerotic plaque (OR, 2.16; 95% CI, 1.70 to 2.75; P<0.001) and significant coronary artery stenosis (OR, 3.34; 95% CI, 2.52 to 4.43; P<0.001) than normal individuals. During a follow-up of median 5.4 years, there was no significant difference in cardiac events between normal and controlled diabetic individuals (P=0.365). However, uncontrolled diabetes was associated with an increased risk of cardiac events compared with normal individuals (P<0.001) and controlled diabetic individuals (P=0.023).ConclusionAsymptomatic uncontrolled diabetes was associated with significant subclinical coronary atherosclerosis with subsequent high risk for cardiac events. |
| first_indexed | 2024-12-14T19:46:06Z |
| format | Article |
| id | doaj.art-1f6fbf552b354080a709cf3846712225 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-14T19:46:06Z |
| publishDate | 2020-06-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-1f6fbf552b354080a709cf38467122252022-12-21T22:49:33ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872020-06-0144347047910.4093/dmj.2019.0073752Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography RegistryGyung-Min Park0Chang Hoon Lee1Seung-Whan Lee2Sung-Cheol Yun3Young-Hak Kim4Yong-Giun Kim5Ki-Bum Won6Soe Hee Ann7Shin-Jae Kim8Dong Hyun Yang9Joon-Won Kang10Tae-Hwan Lim11Eun Hee Koh12Woo Je Lee13Min-Seon Kim14Joong-Yeol Park15Hong-Kyu Kim16Jaewon Choe17Sang-Gon Lee18Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaDepartment of Cardiology, Veterans Health Service Medical Center, Seoul, .KoreaDepartment of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Endocrinology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaThe Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaThe Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, .KoreaBackgroundThere are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis.MethodsWe analyzed 6,434 consecutive asymptomatic individuals without previous history of coronary artery disease who underwent coronary computed tomographic angiography (CCTA) (mean age, 53.7±7.6 years and 4,694 men [73.0%]). The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Study participants were categorized as normal (n=5,319), controlled diabetes (glycosylated hemoglobin [HbA1c] <7%, n=747), or uncontrolled diabetes (HbA1c ≥7%, n=368), respectively.ResultsCompared with normal individuals, there were no statistically significant differences in the risk of for any atherosclerotic plaque (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.98 to 1.38; P=0.086) and significant coronary artery stenosis (OR, 1.08; 95% CI, 0.82 to 1.42; P=0.583) in controlled diabetic individuals. In contrast, uncontrolled diabetic individuals had consistently higher risks of any atherosclerotic plaque (OR, 2.16; 95% CI, 1.70 to 2.75; P<0.001) and significant coronary artery stenosis (OR, 3.34; 95% CI, 2.52 to 4.43; P<0.001) than normal individuals. During a follow-up of median 5.4 years, there was no significant difference in cardiac events between normal and controlled diabetic individuals (P=0.365). However, uncontrolled diabetes was associated with an increased risk of cardiac events compared with normal individuals (P<0.001) and controlled diabetic individuals (P=0.023).ConclusionAsymptomatic uncontrolled diabetes was associated with significant subclinical coronary atherosclerosis with subsequent high risk for cardiac events.http://e-dmj.org/upload/pdf/dmj-44-470.pdfatherosclerosiscoronary artery diseasediabetes complicationsdiabetes mellitus |
| spellingShingle | Gyung-Min Park Chang Hoon Lee Seung-Whan Lee Sung-Cheol Yun Young-Hak Kim Yong-Giun Kim Ki-Bum Won Soe Hee Ann Shin-Jae Kim Dong Hyun Yang Joon-Won Kang Tae-Hwan Lim Eun Hee Koh Woo Je Lee Min-Seon Kim Joong-Yeol Park Hong-Kyu Kim Jaewon Choe Sang-Gon Lee Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry Diabetes & Metabolism Journal atherosclerosis coronary artery disease diabetes complications diabetes mellitus |
| title | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry |
| title_full | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry |
| title_fullStr | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry |
| title_full_unstemmed | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry |
| title_short | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry |
| title_sort | impact of diabetes control on subclinical atherosclerosis analysis from coronary computed tomographic angiography registry |
| topic | atherosclerosis coronary artery disease diabetes complications diabetes mellitus |
| url | http://e-dmj.org/upload/pdf/dmj-44-470.pdf |
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