A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India
<p>Abstract</p> <p>Background</p> <p>A focal H5N1 outbreak in poultry was reported from Manipur, a north-eastern state, of India, in 2007. The aim of this study was to genetically characterize the Manipur isolate to understand the relationship with other H5N1 isolates a...
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| Format: | Article |
| Language: | English |
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BMC
2009-02-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/6/1/26 |
| _version_ | 1818525299987447808 |
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| author | Raut Satish Pal Biswajoy Jadhav Santosh M Pawar Shailesh D Chakrabarti Alok K Cherian Sarah S Mishra Akhilesh C Koratkar Santosh Kode Sadhana S |
| author_facet | Raut Satish Pal Biswajoy Jadhav Santosh M Pawar Shailesh D Chakrabarti Alok K Cherian Sarah S Mishra Akhilesh C Koratkar Santosh Kode Sadhana S |
| author_sort | Raut Satish |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>A focal H5N1 outbreak in poultry was reported from Manipur, a north-eastern state, of India, in 2007. The aim of this study was to genetically characterize the Manipur isolate to understand the relationship with other H5N1 isolates and to trace the possible source of introduction of the virus into the country.</p> <p>Results</p> <p>Characterization of the complete genome revealed that the virus belonged to clade 2.2. It was distinctly different from viruses of the three EMA sublineages of clade 2.2 but related to isolates from wild migratory waterfowl from Russia, China and Mongolia. The HA gene, had the cleavage site GERRRRKR, earlier reported in whooper swan isolates from Mongolia in 2005. A stop codon at position 29 in the PB1-F2 protein could have implications on the replication efficiency. The acquisition of polymorphisms as seen in recent isolates of 2005–07 from distinct geographical regions suggests the possibility of transportation of H5N1 viruses through migratory birds.</p> <p>Conclusion</p> <p>Considering that all eight genes of the earlier Indian isolates belonged to the EMA3 sublineage and similar strains have not been reported from neighbouring countries of the subcontinent, it appears that the virus may have been introduced independently.</p> |
| first_indexed | 2024-12-11T06:07:37Z |
| format | Article |
| id | doaj.art-1f70b7497beb485f9d6bd74a5711c1e2 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-11T06:07:37Z |
| publishDate | 2009-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-1f70b7497beb485f9d6bd74a5711c1e22022-12-22T01:18:15ZengBMCVirology Journal1743-422X2009-02-01612610.1186/1743-422X-6-26A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, IndiaRaut SatishPal BiswajoyJadhav Santosh MPawar Shailesh DChakrabarti Alok KCherian Sarah SMishra Akhilesh CKoratkar SantoshKode Sadhana S<p>Abstract</p> <p>Background</p> <p>A focal H5N1 outbreak in poultry was reported from Manipur, a north-eastern state, of India, in 2007. The aim of this study was to genetically characterize the Manipur isolate to understand the relationship with other H5N1 isolates and to trace the possible source of introduction of the virus into the country.</p> <p>Results</p> <p>Characterization of the complete genome revealed that the virus belonged to clade 2.2. It was distinctly different from viruses of the three EMA sublineages of clade 2.2 but related to isolates from wild migratory waterfowl from Russia, China and Mongolia. The HA gene, had the cleavage site GERRRRKR, earlier reported in whooper swan isolates from Mongolia in 2005. A stop codon at position 29 in the PB1-F2 protein could have implications on the replication efficiency. The acquisition of polymorphisms as seen in recent isolates of 2005–07 from distinct geographical regions suggests the possibility of transportation of H5N1 viruses through migratory birds.</p> <p>Conclusion</p> <p>Considering that all eight genes of the earlier Indian isolates belonged to the EMA3 sublineage and similar strains have not been reported from neighbouring countries of the subcontinent, it appears that the virus may have been introduced independently.</p>http://www.virologyj.com/content/6/1/26 |
| spellingShingle | Raut Satish Pal Biswajoy Jadhav Santosh M Pawar Shailesh D Chakrabarti Alok K Cherian Sarah S Mishra Akhilesh C Koratkar Santosh Kode Sadhana S A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India Virology Journal |
| title | A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India |
| title_full | A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India |
| title_fullStr | A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India |
| title_full_unstemmed | A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India |
| title_short | A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India |
| title_sort | unique influenza a h5n1 virus causing a focal poultry outbreak in 2007 in manipur india |
| url | http://www.virologyj.com/content/6/1/26 |
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