Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study
Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rate...
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/22/5433 |
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| author | Christian Hoffmann Toke Ringbaek Anja Eckstein Wolfgang Deya Alina Santiago Martin Heintz Wolfgang Lübcke Frank Indenkämpen Wolfgang Sauerwein Andrea Flühs Claudia Le Guin Andreas Huettmann Julia von Tresckow Sophia Göricke Cornelius Deuschl Sourour Moliavi Christoph Poettgen Thomas Gauler Nika Guberina Patricia Johansson Nikolaos Bechrakis Martin Stuschke Maja Guberina |
| author_facet | Christian Hoffmann Toke Ringbaek Anja Eckstein Wolfgang Deya Alina Santiago Martin Heintz Wolfgang Lübcke Frank Indenkämpen Wolfgang Sauerwein Andrea Flühs Claudia Le Guin Andreas Huettmann Julia von Tresckow Sophia Göricke Cornelius Deuschl Sourour Moliavi Christoph Poettgen Thomas Gauler Nika Guberina Patricia Johansson Nikolaos Bechrakis Martin Stuschke Maja Guberina |
| author_sort | Christian Hoffmann |
| collection | DOAJ |
| description | Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients with strictly conjunctival, low-grade Ann Arbor stage IE lymphoma treated with superficial electron irradiation between 1999 and 2021 at our department were reviewed. A total of 56 patients with 65 treated eyes were enrolled with a median follow-up of 65 months. The median dose was 30.96 Gy. A lens-spearing technique featuring a hanging rod blocking the central beam axis was used in 89.2% of all cases. Cumulative incidences of 5- and 10-year infield recurrences were 4.3% and 14.6%, incidences of 5- and 10-year outfield progression were 10.4% and 13.4%. We used patients with involvement of retroorbital structures treated with whole-orbit photon irradiation without lens protection—of which we reported in a previous study—as a control group. The cumulative cataract incidence for patients treated with electrons and lens protection was significantly lower (<i>p</i> = 0.005) when compared to patients irradiated without lens protection. Thus, electrons are an effective treatment option for conjunctival low-grade lymphomas. The presented lens-sparing technique effectively prevents cataract formation. |
| first_indexed | 2024-03-09T16:56:24Z |
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| id | doaj.art-1f72176476844e04ab50c39601f48da3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T16:56:24Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1f72176476844e04ab50c39601f48da32023-11-24T14:34:26ZengMDPI AGCancers2072-66942023-11-011522543310.3390/cancers15225433Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal StudyChristian Hoffmann0Toke Ringbaek1Anja Eckstein2Wolfgang Deya3Alina Santiago4Martin Heintz5Wolfgang Lübcke6Frank Indenkämpen7Wolfgang Sauerwein8Andrea Flühs9Claudia Le Guin10Andreas Huettmann11Julia von Tresckow12Sophia Göricke13Cornelius Deuschl14Sourour Moliavi15Christoph Poettgen16Thomas Gauler17Nika Guberina18Patricia Johansson19Nikolaos Bechrakis20Martin Stuschke21Maja Guberina22Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyNational Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyIrradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients with strictly conjunctival, low-grade Ann Arbor stage IE lymphoma treated with superficial electron irradiation between 1999 and 2021 at our department were reviewed. A total of 56 patients with 65 treated eyes were enrolled with a median follow-up of 65 months. The median dose was 30.96 Gy. A lens-spearing technique featuring a hanging rod blocking the central beam axis was used in 89.2% of all cases. Cumulative incidences of 5- and 10-year infield recurrences were 4.3% and 14.6%, incidences of 5- and 10-year outfield progression were 10.4% and 13.4%. We used patients with involvement of retroorbital structures treated with whole-orbit photon irradiation without lens protection—of which we reported in a previous study—as a control group. The cumulative cataract incidence for patients treated with electrons and lens protection was significantly lower (<i>p</i> = 0.005) when compared to patients irradiated without lens protection. Thus, electrons are an effective treatment option for conjunctival low-grade lymphomas. The presented lens-sparing technique effectively prevents cataract formation.https://www.mdpi.com/2072-6694/15/22/5433conjunctival lymphomaocular adnexal tumorsMALT lymphomasradiotherapyelectronslens sparing |
| spellingShingle | Christian Hoffmann Toke Ringbaek Anja Eckstein Wolfgang Deya Alina Santiago Martin Heintz Wolfgang Lübcke Frank Indenkämpen Wolfgang Sauerwein Andrea Flühs Claudia Le Guin Andreas Huettmann Julia von Tresckow Sophia Göricke Cornelius Deuschl Sourour Moliavi Christoph Poettgen Thomas Gauler Nika Guberina Patricia Johansson Nikolaos Bechrakis Martin Stuschke Maja Guberina Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study Cancers conjunctival lymphoma ocular adnexal tumors MALT lymphomas radiotherapy electrons lens sparing |
| title | Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study |
| title_full | Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study |
| title_fullStr | Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study |
| title_full_unstemmed | Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study |
| title_short | Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study |
| title_sort | long term follow up of patients with conjunctival lymphoma after individualized lens sparing electron radiotherapy results from a longitudinal study |
| topic | conjunctival lymphoma ocular adnexal tumors MALT lymphomas radiotherapy electrons lens sparing |
| url | https://www.mdpi.com/2072-6694/15/22/5433 |
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