The impact of pulmonary cachexia on inpatient outcomes: A national study
BACKGROUND: Cachexia has been associated with chronic lung disease (pulmonary cachexia syndrome), which is associated with increased mortality. However, studies that looked into this association was relatively small, and national level data are lacking. Herein, we aim to study the association betwee...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=3;spage=156;epage=161;aulast=Alahmad |
| _version_ | 1797738844505767936 |
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| author | Mohamad Alhoda Mohamad Alahmad Cheryl A Gibson |
| author_facet | Mohamad Alhoda Mohamad Alahmad Cheryl A Gibson |
| author_sort | Mohamad Alhoda Mohamad Alahmad |
| collection | DOAJ |
| description | BACKGROUND: Cachexia has been associated with chronic lung disease (pulmonary cachexia syndrome), which is associated with increased mortality. However, studies that looked into this association was relatively small, and national level data are lacking. Herein, we aim to study the association between chronic obstructive lung disease (COPD) and cachexia.
RESEARCH QUESTION: Do patients with COPD and cachexia has worse inpatient outcomes in comparison to those with no cachexia?
STUDY DESIGN AND METHODS: We used the Nationwide Readmissions Database from 2016 to 2019, extracting adult patients with a primary diagnosis of COPD who were admitted between January and November of each year studied. We excluded patients with missing data on event time or length of stay. Furthermore, we excluded all cases with cormobidities associated with cachexia. We used SAS 9.4 for data exploration and analysis.
RESULTS: We included 1,446,431 COPD-related weighted hospitalizations for which 115,276 cases (7.9%) had a concurrent diagnosis of cachexia (or cachexia-related diagnoses). Overall, patients with cachexia (COPD-C), compared to patients with COPD and no cachexia (COPD-NC), were older (mean age 69 vs. 66 years, respectively, P < 0.001) with similar gender distribution (58%). COPD-C patients had more inpatient complications including cardiac arrest, and use of mechanical ventilation (P < 0.001). Furthermore, they had longer mean lengths of stay (5.2 days vs. 3.8 days, P < 0.001). In-hospital mortality during index, admission was significantly higher in these patients at 2.2% compared to 0.5% for COPD-NC (P < 0.001).
CONCLUSION: COPD-related cachexia is associated with increased inpatient mortality, resource utilization, and prolonged hospitalization. |
| first_indexed | 2024-03-12T13:48:45Z |
| format | Article |
| id | doaj.art-1f7439c5fc8444fcbede0266407f820d |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-03-12T13:48:45Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-1f7439c5fc8444fcbede0266407f820d2023-08-23T07:27:21ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572023-01-0118315616110.4103/atm.atm_31_23The impact of pulmonary cachexia on inpatient outcomes: A national studyMohamad Alhoda Mohamad AlahmadCheryl A GibsonBACKGROUND: Cachexia has been associated with chronic lung disease (pulmonary cachexia syndrome), which is associated with increased mortality. However, studies that looked into this association was relatively small, and national level data are lacking. Herein, we aim to study the association between chronic obstructive lung disease (COPD) and cachexia. RESEARCH QUESTION: Do patients with COPD and cachexia has worse inpatient outcomes in comparison to those with no cachexia? STUDY DESIGN AND METHODS: We used the Nationwide Readmissions Database from 2016 to 2019, extracting adult patients with a primary diagnosis of COPD who were admitted between January and November of each year studied. We excluded patients with missing data on event time or length of stay. Furthermore, we excluded all cases with cormobidities associated with cachexia. We used SAS 9.4 for data exploration and analysis. RESULTS: We included 1,446,431 COPD-related weighted hospitalizations for which 115,276 cases (7.9%) had a concurrent diagnosis of cachexia (or cachexia-related diagnoses). Overall, patients with cachexia (COPD-C), compared to patients with COPD and no cachexia (COPD-NC), were older (mean age 69 vs. 66 years, respectively, P < 0.001) with similar gender distribution (58%). COPD-C patients had more inpatient complications including cardiac arrest, and use of mechanical ventilation (P < 0.001). Furthermore, they had longer mean lengths of stay (5.2 days vs. 3.8 days, P < 0.001). In-hospital mortality during index, admission was significantly higher in these patients at 2.2% compared to 0.5% for COPD-NC (P < 0.001). CONCLUSION: COPD-related cachexia is associated with increased inpatient mortality, resource utilization, and prolonged hospitalization.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=3;spage=156;epage=161;aulast=Alahmadcachexiachronic obstructive pulmonary diseaseinpatient mortalitynationwide readmissions database |
| spellingShingle | Mohamad Alhoda Mohamad Alahmad Cheryl A Gibson The impact of pulmonary cachexia on inpatient outcomes: A national study Annals of Thoracic Medicine cachexia chronic obstructive pulmonary disease inpatient mortality nationwide readmissions database |
| title | The impact of pulmonary cachexia on inpatient outcomes: A national study |
| title_full | The impact of pulmonary cachexia on inpatient outcomes: A national study |
| title_fullStr | The impact of pulmonary cachexia on inpatient outcomes: A national study |
| title_full_unstemmed | The impact of pulmonary cachexia on inpatient outcomes: A national study |
| title_short | The impact of pulmonary cachexia on inpatient outcomes: A national study |
| title_sort | impact of pulmonary cachexia on inpatient outcomes a national study |
| topic | cachexia chronic obstructive pulmonary disease inpatient mortality nationwide readmissions database |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2023;volume=18;issue=3;spage=156;epage=161;aulast=Alahmad |
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