Use of the 2D <sup>1</sup>H-<sup>13</sup>C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

Use of the 2D <sup>1</sup>H-<sup>13</sup>C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution, such as Fourier transform infrared (FTIR), circul...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Tsang-Lin Hwang, Dipanwita Batabyal, Nicholas Knutson, Mats Wikström
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: MDPI AG 2021-05-01
Sarja:Molecules
Aiheet:
higher-order structure
tertiary structure
fluorescence
circular dichroism
NMR
HOS by NMR
Linkit:https://www.mdpi.com/1420-3049/26/9/2714

Internet

https://www.mdpi.com/1420-3049/26/9/2714

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