A Summary on Tuberculosis Vaccine Development—Where to Go?
Background: Tuberculosis (TB) is an old infectious disease caused by <i>Mycobacterium tuberculosis</i> infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/3/408 |
| _version_ | 1797610782303715328 |
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| author | Fan Jiang Tiehui Sun Peng Cheng Jie Wang Wenping Gong |
| author_facet | Fan Jiang Tiehui Sun Peng Cheng Jie Wang Wenping Gong |
| author_sort | Fan Jiang |
| collection | DOAJ |
| description | Background: Tuberculosis (TB) is an old infectious disease caused by <i>Mycobacterium tuberculosis</i> infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine research from a bibliometric perspective. This study was conducted to examine the development of TB vaccines over the past 20 years and to identify research priorities and directions for the future. Methods: The Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WOSCC) database was selected to search the literature related to TB vaccines. The countries, institutions, authors, journals, references, and keywords of each publication were analyzed and visualized using the VOSviewer, CiteSpace, and Bibliometrix software. Furthermore, GraphPad Prism and Microsoft Excel 365 were also used for statistical analysis. Results: As of 20 October 2022, 7960 publications related to TB vaccines were identified with 288,478 citations. The United States of America (USA) accounted for the largest share (2658, 33.40%), followed by the United Kingdom (UK, 1301, 16.34%), and China (685, 8.6%). Regarding affiliations, the University of London had the most publications (427) and shared the highest H-index (76) with the Statens Serum Institut of Denmark. In terms of the number of articles for the journals and authors, the journal Vaccine ranked first with 629 articles. Professor Peter Anderssen has published the highest number of papers (160). The burst keywords and thematic maps analysis showed that future trends in TB vaccine development would focus on exploring the interaction mechanisms between <i>M. tuberculosis</i> and the host. Conclusion: The number of publications on TB vaccines has grown over the past two decades. Developed countries play a significant role in TB vaccine research, and developing countries are fast catching up. We believe that future research will be aimed at understanding the fine molecular mechanisms of host–pathogen interaction, leading to the development of better TB vaccines. |
| first_indexed | 2024-03-11T06:18:53Z |
| format | Article |
| id | doaj.art-1f777e3ea3ff43fe8782e59e96650e5c |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T06:18:53Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-1f777e3ea3ff43fe8782e59e96650e5c2023-11-17T12:01:54ZengMDPI AGJournal of Personalized Medicine2075-44262023-02-0113340810.3390/jpm13030408A Summary on Tuberculosis Vaccine Development—Where to Go?Fan Jiang0Tiehui Sun1Peng Cheng2Jie Wang3Wenping Gong4Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, ChinaDepartment of Gastroenterology, Zhang Jia Kou Fifth Hospital, Zhangjiakou 075051, ChinaTuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, ChinaTuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, ChinaTuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, ChinaBackground: Tuberculosis (TB) is an old infectious disease caused by <i>Mycobacterium tuberculosis</i> infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine research from a bibliometric perspective. This study was conducted to examine the development of TB vaccines over the past 20 years and to identify research priorities and directions for the future. Methods: The Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WOSCC) database was selected to search the literature related to TB vaccines. The countries, institutions, authors, journals, references, and keywords of each publication were analyzed and visualized using the VOSviewer, CiteSpace, and Bibliometrix software. Furthermore, GraphPad Prism and Microsoft Excel 365 were also used for statistical analysis. Results: As of 20 October 2022, 7960 publications related to TB vaccines were identified with 288,478 citations. The United States of America (USA) accounted for the largest share (2658, 33.40%), followed by the United Kingdom (UK, 1301, 16.34%), and China (685, 8.6%). Regarding affiliations, the University of London had the most publications (427) and shared the highest H-index (76) with the Statens Serum Institut of Denmark. In terms of the number of articles for the journals and authors, the journal Vaccine ranked first with 629 articles. Professor Peter Anderssen has published the highest number of papers (160). The burst keywords and thematic maps analysis showed that future trends in TB vaccine development would focus on exploring the interaction mechanisms between <i>M. tuberculosis</i> and the host. Conclusion: The number of publications on TB vaccines has grown over the past two decades. Developed countries play a significant role in TB vaccine research, and developing countries are fast catching up. We believe that future research will be aimed at understanding the fine molecular mechanisms of host–pathogen interaction, leading to the development of better TB vaccines.https://www.mdpi.com/2075-4426/13/3/408tuberculosisvaccine<i>Mycobacterium tuberculosis</i>bibliometric analysisimmunity |
| spellingShingle | Fan Jiang Tiehui Sun Peng Cheng Jie Wang Wenping Gong A Summary on Tuberculosis Vaccine Development—Where to Go? Journal of Personalized Medicine tuberculosis vaccine <i>Mycobacterium tuberculosis</i> bibliometric analysis immunity |
| title | A Summary on Tuberculosis Vaccine Development—Where to Go? |
| title_full | A Summary on Tuberculosis Vaccine Development—Where to Go? |
| title_fullStr | A Summary on Tuberculosis Vaccine Development—Where to Go? |
| title_full_unstemmed | A Summary on Tuberculosis Vaccine Development—Where to Go? |
| title_short | A Summary on Tuberculosis Vaccine Development—Where to Go? |
| title_sort | summary on tuberculosis vaccine development where to go |
| topic | tuberculosis vaccine <i>Mycobacterium tuberculosis</i> bibliometric analysis immunity |
| url | https://www.mdpi.com/2075-4426/13/3/408 |
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