11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma
Abstract The optimal method of tumor burden evaluation in newly diagnosed multiple myeloma (NDMM) is yet to be determined. This study aimed to compare the value of 11C-acetate positron-emission tomography (PET)/computed tomography (CT) (AC-PET and 18F-fluorodeoxyglucose PET/CT (FDG-PET) in the asses...
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| Format: | Article |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01740-2 |
| _version_ | 1818837060552753152 |
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| author | Miao Chen Wenjia Zhu Jianhua Du Chen Yang Bing Han Daobin Zhou Li Huo Junling Zhuang |
| author_facet | Miao Chen Wenjia Zhu Jianhua Du Chen Yang Bing Han Daobin Zhou Li Huo Junling Zhuang |
| author_sort | Miao Chen |
| collection | DOAJ |
| description | Abstract The optimal method of tumor burden evaluation in newly diagnosed multiple myeloma (NDMM) is yet to be determined. This study aimed to compare the value of 11C-acetate positron-emission tomography (PET)/computed tomography (CT) (AC-PET and 18F-fluorodeoxyglucose PET/CT (FDG-PET) in the assessment of tumor burden in NDMM. This study evaluated 64 NDMM patients between February 2015 and July 2018. AC-PET and FDG-PET were used to assess myeloma lesions. The clinical data, imaging results, and their correlations were analyzed. Diffuse bone marrow uptake in AC-PET was significantly correlated with biomarkers for tumor burden, including serum hemoglobin (P = 0.020), M protein (P = 0.054), the percentage of bone marrow plasma cells (P < 0.001), and the Durie–Salmon stage of the disease (P = 0.007). The maximum standard uptake value (SUVmax) of focal lesions and high diffuse bone marrow uptake in AC-PET showed stronger correlations with high-risk disease (P = 0.017, P = 0.013) than those in FDG-PET. Moreover, the presence of diffuse bone marrow uptake, more than ten focal lesions, and an SUVmax of focal lesions of > 6.0 in AC-PET, but not in FDG-PET, predicted a higher probability of disease progression and shorter progression-free survival (P < 0.05). AC-PET outperformed FDG-PET in tumor burden evaluation and disease progression prediction in NDMM. |
| first_indexed | 2024-12-19T03:16:30Z |
| format | Article |
| id | doaj.art-1f77fa28b9db4d918610f808c0a0606d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T03:16:30Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1f77fa28b9db4d918610f808c0a0606d2022-12-21T20:37:52ZengNature PortfolioScientific Reports2045-23222021-11-0111111010.1038/s41598-021-01740-211C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myelomaMiao Chen0Wenjia Zhu1Jianhua Du2Chen Yang3Bing Han4Daobin Zhou5Li Huo6Junling Zhuang7Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesDepartment of Hematology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical SciencesAbstract The optimal method of tumor burden evaluation in newly diagnosed multiple myeloma (NDMM) is yet to be determined. This study aimed to compare the value of 11C-acetate positron-emission tomography (PET)/computed tomography (CT) (AC-PET and 18F-fluorodeoxyglucose PET/CT (FDG-PET) in the assessment of tumor burden in NDMM. This study evaluated 64 NDMM patients between February 2015 and July 2018. AC-PET and FDG-PET were used to assess myeloma lesions. The clinical data, imaging results, and their correlations were analyzed. Diffuse bone marrow uptake in AC-PET was significantly correlated with biomarkers for tumor burden, including serum hemoglobin (P = 0.020), M protein (P = 0.054), the percentage of bone marrow plasma cells (P < 0.001), and the Durie–Salmon stage of the disease (P = 0.007). The maximum standard uptake value (SUVmax) of focal lesions and high diffuse bone marrow uptake in AC-PET showed stronger correlations with high-risk disease (P = 0.017, P = 0.013) than those in FDG-PET. Moreover, the presence of diffuse bone marrow uptake, more than ten focal lesions, and an SUVmax of focal lesions of > 6.0 in AC-PET, but not in FDG-PET, predicted a higher probability of disease progression and shorter progression-free survival (P < 0.05). AC-PET outperformed FDG-PET in tumor burden evaluation and disease progression prediction in NDMM.https://doi.org/10.1038/s41598-021-01740-2 |
| spellingShingle | Miao Chen Wenjia Zhu Jianhua Du Chen Yang Bing Han Daobin Zhou Li Huo Junling Zhuang 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma Scientific Reports |
| title | 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| title_full | 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| title_fullStr | 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| title_full_unstemmed | 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| title_short | 11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| title_sort | 11c acetate positron emission tomography is more precise than 18f fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting disease risk of multiple myeloma |
| url | https://doi.org/10.1038/s41598-021-01740-2 |
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