Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol
The potential of proniosomes as a transdermal drug delivery system for Atenolol was investigated by encapsulating the drug in various formulations of proniosomal gel composed of various ratios of sorbitan fatty acid esters, cholesterol, lecithin prepared by Coacervation-phase separation method. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-06-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314724516301029 |
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| author | S. Ramkanth C. Madhusudhana Chetty Y. Sudhakar V.S. Thiruvengadarajan P. Anitha C. Gopinath |
| author_facet | S. Ramkanth C. Madhusudhana Chetty Y. Sudhakar V.S. Thiruvengadarajan P. Anitha C. Gopinath |
| author_sort | S. Ramkanth |
| collection | DOAJ |
| description | The potential of proniosomes as a transdermal drug delivery system for Atenolol was investigated by encapsulating the drug in various formulations of proniosomal gel composed of various ratios of sorbitan fatty acid esters, cholesterol, lecithin prepared by Coacervation-phase separation method. The objectives of the present study were to define effects on the antihypertension activity and pharmacokinetics of a novel transdermal Proniosomal gel incorporating Atenolol. The formulated systems were characterized in vitro for size, drug entrapment, In vitro and in vivo drug permeation profiles and vesicular stability at different storage conditions. The optimized Atenolol proniosomes (AT8) showed nanometric vesicle size, high entrapment efficiency and marked enhancement in transdermal permeation. The prepared Proniosomal gel showed the relative bioavailability of 365.38 fold increased for AT8 than oral. The maximal concentrations (Cmax), of drug were significantly reduced while the areas under the plasma concentration–time curve (AUC), and mean residence times (MRT), t1/2 were evidently increased and extended, respectively. The results suggest that proniosomes can act as promising carrier which offers an alternative approach for transdermal delivery of Atenolol. Keywords: Proniosomes, Atenolol, Niosomes, Pharmacokinetic study, Transdermal delivery |
| first_indexed | 2024-12-10T11:56:14Z |
| format | Article |
| id | doaj.art-1f780179d2cb4dd98c6a1d2644b937e6 |
| institution | Directory Open Access Journal |
| issn | 2314-7245 |
| language | English |
| last_indexed | 2024-12-10T11:56:14Z |
| publishDate | 2018-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-1f780179d2cb4dd98c6a1d2644b937e62022-12-22T01:49:47ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72452018-06-01418087Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of AtenololS. Ramkanth0C. Madhusudhana Chetty1Y. Sudhakar2V.S. Thiruvengadarajan3P. Anitha4C. Gopinath5Annamacharya College of Pharmacy, Rajampet, 516126, Andhra Pradesh, India; Corresponding author. Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, 516126, Andhra Pradesh, India. Tel.: +91 9618312122.Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, IndiaS V Government Polytechnic, Tirupathi, Andhra Pradesh, IndiaAnnamacharya College of Pharmacy, Rajampet, 516126, Andhra Pradesh, IndiaAnnamacharya College of Pharmacy, Rajampet, 516126, Andhra Pradesh, IndiaAnnamacharya College of Pharmacy, Rajampet, 516126, Andhra Pradesh, IndiaThe potential of proniosomes as a transdermal drug delivery system for Atenolol was investigated by encapsulating the drug in various formulations of proniosomal gel composed of various ratios of sorbitan fatty acid esters, cholesterol, lecithin prepared by Coacervation-phase separation method. The objectives of the present study were to define effects on the antihypertension activity and pharmacokinetics of a novel transdermal Proniosomal gel incorporating Atenolol. The formulated systems were characterized in vitro for size, drug entrapment, In vitro and in vivo drug permeation profiles and vesicular stability at different storage conditions. The optimized Atenolol proniosomes (AT8) showed nanometric vesicle size, high entrapment efficiency and marked enhancement in transdermal permeation. The prepared Proniosomal gel showed the relative bioavailability of 365.38 fold increased for AT8 than oral. The maximal concentrations (Cmax), of drug were significantly reduced while the areas under the plasma concentration–time curve (AUC), and mean residence times (MRT), t1/2 were evidently increased and extended, respectively. The results suggest that proniosomes can act as promising carrier which offers an alternative approach for transdermal delivery of Atenolol. Keywords: Proniosomes, Atenolol, Niosomes, Pharmacokinetic study, Transdermal deliveryhttp://www.sciencedirect.com/science/article/pii/S2314724516301029 |
| spellingShingle | S. Ramkanth C. Madhusudhana Chetty Y. Sudhakar V.S. Thiruvengadarajan P. Anitha C. Gopinath Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol Future Journal of Pharmaceutical Sciences |
| title | Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol |
| title_full | Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol |
| title_fullStr | Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol |
| title_full_unstemmed | Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol |
| title_short | Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol |
| title_sort | development characterization invivo evaluation of proniosomal based transdermal delivery system of atenolol |
| url | http://www.sciencedirect.com/science/article/pii/S2314724516301029 |
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