Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice

Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice

Objective: To evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice. Methods: The BKO mice were fed with a ferrocene-rich diet and were orally administ...

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Bibliographic Details
Main Authors: Kanokwan Kulprachakarn, Nittaya Chansiw, Kanjana Pangjit, Chada Phisalaphong, Suthat Fucharoen, Robert C. Hider, Sineenart Santitherakul, Somdet Srichairatanakool
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-08-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
Iron-chelating
Iron overload
β-thalassemia
Iron chelator
Non-transferrin bound iron
Lipid peroxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2221169115300848

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