Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.

Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DN...

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Bibliographic Details
Main Authors: Ramanagouda Ramanagoudr-Bhojappa, Blake Carrington, Mukundhan Ramaswami, Kevin Bishop, Gabrielle M Robbins, MaryPat Jones, Ursula Harper, Stephen C Frederickson, Danielle C Kimble, Raman Sood, Settara C Chandrasekharappa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007821

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