Laboratory information management system for COVID-19 non-clinical efficacy trial data
Abstract Background As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42826-022-00127-2 |
| _version_ | 1818234262796632064 |
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| author | Suhyeon Yoon Hyuna Noh Heejin Jin Sungyoung Lee Soyul Han Sung-Hee Kim Jiseon Kim Jung Seon Seo Jeong Jin Kim In Ho Park Jooyeon Oh Joon-Yong Bae Gee Eun Lee Sun-Je Woo Sun-Min Seo Na-Won Kim Youn Woo Lee Hui Jeong Jang Seung-Min Hong Se-Hee An Kwang-Soo Lyoo Minjoo Yeom Hanbyeul Lee Bud Jung Sun-Woo Yoon Jung-Ah Kang Sang-Hyuk Seok Yu Jin Lee Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Dain On Soo-Yeon Lim Sol Pin Kim Ji Yun Jang Ho Lee Kyoungmi Kim Hyo-Jung Lee Hong Bin Kim Jun Won Park Dae Gwin Jeong Daesub Song Kang-Seuk Choi Ho-Young Lee Yang-Kyu Choi Jung-ah Choi Manki Song Man-Seong Park Jun-Young Seo Ki Taek Nam Jeon-Soo Shin Sungho Won Jun-Won Yun Je Kyung Seong |
| author_facet | Suhyeon Yoon Hyuna Noh Heejin Jin Sungyoung Lee Soyul Han Sung-Hee Kim Jiseon Kim Jung Seon Seo Jeong Jin Kim In Ho Park Jooyeon Oh Joon-Yong Bae Gee Eun Lee Sun-Je Woo Sun-Min Seo Na-Won Kim Youn Woo Lee Hui Jeong Jang Seung-Min Hong Se-Hee An Kwang-Soo Lyoo Minjoo Yeom Hanbyeul Lee Bud Jung Sun-Woo Yoon Jung-Ah Kang Sang-Hyuk Seok Yu Jin Lee Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Dain On Soo-Yeon Lim Sol Pin Kim Ji Yun Jang Ho Lee Kyoungmi Kim Hyo-Jung Lee Hong Bin Kim Jun Won Park Dae Gwin Jeong Daesub Song Kang-Seuk Choi Ho-Young Lee Yang-Kyu Choi Jung-ah Choi Manki Song Man-Seong Park Jun-Young Seo Ki Taek Nam Jeon-Soo Shin Sungho Won Jun-Won Yun Je Kyung Seong |
| author_sort | Suhyeon Yoon |
| collection | DOAJ |
| description | Abstract Background As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research. Results In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research. Conclusions This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies. |
| first_indexed | 2024-12-12T11:35:17Z |
| format | Article |
| id | doaj.art-1f7bd34077c741f686d86cc851df1bee |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-12-12T11:35:17Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-1f7bd34077c741f686d86cc851df1bee2022-12-22T00:25:40ZengBMCLaboratory Animal Research2233-76602022-06-013811910.1186/s42826-022-00127-2Laboratory information management system for COVID-19 non-clinical efficacy trial dataSuhyeon Yoon0Hyuna Noh1Heejin Jin2Sungyoung Lee3Soyul Han4Sung-Hee Kim5Jiseon Kim6Jung Seon Seo7Jeong Jin Kim8In Ho Park9Jooyeon Oh10Joon-Yong Bae11Gee Eun Lee12Sun-Je Woo13Sun-Min Seo14Na-Won Kim15Youn Woo Lee16Hui Jeong Jang17Seung-Min Hong18Se-Hee An19Kwang-Soo Lyoo20Minjoo Yeom21Hanbyeul Lee22Bud Jung23Sun-Woo Yoon24Jung-Ah Kang25Sang-Hyuk Seok26Yu Jin Lee27Seo Yeon Kim28Young Been Kim29Ji-Yeon Hwang30Dain On31Soo-Yeon Lim32Sol Pin Kim33Ji Yun Jang34Ho Lee35Kyoungmi Kim36Hyo-Jung Lee37Hong Bin Kim38Jun Won Park39Dae Gwin Jeong40Daesub Song41Kang-Seuk Choi42Ho-Young Lee43Yang-Kyu Choi44Jung-ah Choi45Manki Song46Man-Seong Park47Jun-Young Seo48Ki Taek Nam49Jeon-Soo Shin50Sungho Won51Jun-Won Yun52Je Kyung Seong53Korea Mouse Phenotyping Center, Seoul National UniversityKorea Mouse Phenotyping Center, Seoul National UniversityInstitute of Health and Environment, Seoul National UniversityDepartment of Genomic Medicine, Seoul National University HospitalRexSoft CorpSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineDepartment of Microbiology, Yonsei University College of MedicineDepartment of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of MedicineDepartment of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of MedicineScience Unit, International Vaccine InstituteDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk UniversityDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk UniversityDepartment of Nuclear Medicine, Seoul National University Bundang HospitalDepartment of Nuclear Medicine, Seoul National University Bundang HospitalLaboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National UniversityLaboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National UniversityKorea Zoonosis Research Institute, Chonbuk National UniversityDepartment of Pharmacy, College of Pharmacy, Korea UniversityDepartment of Pharmacy, College of Pharmacy, Korea UniversityDepartment of Pharmacy, College of Pharmacy, Korea UniversityBionanotechnology Research Center, Korea Research Institute of Bioscience and BiotechnologyBionanotechnology Research Center, Korea Research Institute of Bioscience and BiotechnologyDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National UniversityDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National UniversityPreclinical Research Center, Seoul National University Bundang HospitalPreclinical Research Center, Seoul National University Bundang HospitalPreclinical Research Center, Seoul National University Bundang HospitalKorea Mouse Phenotyping Center, Seoul National UniversityKorea Mouse Phenotyping Center, Seoul National UniversityKorea Mouse Phenotyping Center, Seoul National UniversityGraduate School of Cancer Science and Policy, National Cancer CenterGraduate School of Cancer Science and Policy, National Cancer CenterDepartment of Biomedical Sciences and Department of Physiology, Korea University College of MedicineDepartment of Periodontology, Section of Dentistry, Seoul National University Bundang HospitalDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National UniversityBionanotechnology Research Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Pharmacy, College of Pharmacy, Korea UniversityLaboratory of Avian Diseases, BK21 Plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National UniversityDepartment of Nuclear Medicine, Seoul National University Bundang HospitalDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk UniversityScience Unit, International Vaccine InstituteScience Unit, International Vaccine InstituteDepartment of Microbiology, Institute for Viral Diseases, Biosafety Center, Korea University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineSeverance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of MedicineInstitute of Health and Environment, Seoul National UniversityLaboratory of Veterinary Toxicology, College of Veterinary Medicine, Seoul National UniversityKorea Mouse Phenotyping Center, Seoul National UniversityAbstract Background As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research. Results In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research. Conclusions This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies.https://doi.org/10.1186/s42826-022-00127-2SARS-CoV-2COVID-19Non-clinicalLaboratory information management systemData |
| spellingShingle | Suhyeon Yoon Hyuna Noh Heejin Jin Sungyoung Lee Soyul Han Sung-Hee Kim Jiseon Kim Jung Seon Seo Jeong Jin Kim In Ho Park Jooyeon Oh Joon-Yong Bae Gee Eun Lee Sun-Je Woo Sun-Min Seo Na-Won Kim Youn Woo Lee Hui Jeong Jang Seung-Min Hong Se-Hee An Kwang-Soo Lyoo Minjoo Yeom Hanbyeul Lee Bud Jung Sun-Woo Yoon Jung-Ah Kang Sang-Hyuk Seok Yu Jin Lee Seo Yeon Kim Young Been Kim Ji-Yeon Hwang Dain On Soo-Yeon Lim Sol Pin Kim Ji Yun Jang Ho Lee Kyoungmi Kim Hyo-Jung Lee Hong Bin Kim Jun Won Park Dae Gwin Jeong Daesub Song Kang-Seuk Choi Ho-Young Lee Yang-Kyu Choi Jung-ah Choi Manki Song Man-Seong Park Jun-Young Seo Ki Taek Nam Jeon-Soo Shin Sungho Won Jun-Won Yun Je Kyung Seong Laboratory information management system for COVID-19 non-clinical efficacy trial data Laboratory Animal Research SARS-CoV-2 COVID-19 Non-clinical Laboratory information management system Data |
| title | Laboratory information management system for COVID-19 non-clinical efficacy trial data |
| title_full | Laboratory information management system for COVID-19 non-clinical efficacy trial data |
| title_fullStr | Laboratory information management system for COVID-19 non-clinical efficacy trial data |
| title_full_unstemmed | Laboratory information management system for COVID-19 non-clinical efficacy trial data |
| title_short | Laboratory information management system for COVID-19 non-clinical efficacy trial data |
| title_sort | laboratory information management system for covid 19 non clinical efficacy trial data |
| topic | SARS-CoV-2 COVID-19 Non-clinical Laboratory information management system Data |
| url | https://doi.org/10.1186/s42826-022-00127-2 |
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