Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms
Introduction. Increased resistance of microorganisms to traditional antibiotics has created a practical need for isolating and synthesizing new antibiotics. We aimed to study the antibiotic activity and resistance of bacteriocins produced by lactic acid bacteria and other microorganisms. Study obje...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kemerovo State University
2020-10-01
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| Series: | Foods and Raw Materials |
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| Online Access: | http://jfrm.ru/files/archive/16/Yang.pdf |
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| author | Yang Yong Babich Olga O. Sukhikh Stanislav A. Zimina Maria I. Milentyeva Irina S. |
| author_facet | Yang Yong Babich Olga O. Sukhikh Stanislav A. Zimina Maria I. Milentyeva Irina S. |
| author_sort | Yang Yong |
| collection | DOAJ |
| description | Introduction. Increased resistance of microorganisms to traditional antibiotics has created a practical need for isolating and synthesizing new antibiotics. We aimed to study the antibiotic activity and resistance of bacteriocins produced by lactic acid bacteria and other microorganisms.
Study objects and methods. We studied the isolates of the following microorganism strains: Bacillus subtilis, Penicillium glabrum, Penicillium lagena, Pseudomonas koreenis, Penicillium ochrochloron, Leuconostoc lactis, Lactobacillus plantarum, Leuconostoc mesenteroides, Pediococcus acidilactici, Leuconostoc mesenteroides, Pediococcus pentosaceus, Lactobacillus casei, Lactobacillus fermentum, Bacteroides hypermegas, Bacteroides ruminicola, Pediococcus damnosus, Bacteroides paurosaccharolyticus, Halobacillus profundi, Geobacillus stearothermophilus, and Bacillus caldotenax. Pathogenic test strains included Escherichia coli, Salmonella enterica, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus mycoides, Alcaligenes faecalis, and Proteus vulgaris. The titer of microorganisms was determined by optical density measurements at 595 nm.
Results and discussion. We found that eleven microorganisms out of twenty showed high antimicrobial activity against all test strains of pathogenic and opportunistic microorganisms. All the Bacteroides strains exhibited little antimicrobial activity against Gramnegative test strains, while Halobacillus profundi had an inhibitory effect on Gram-positive species only. The Penicillium strains also displayed a slight antimicrobial effect on pathogenic test strains.
Conclusion. The antibiotic resistance of the studied lactic acid bacteria and other bacteriocin-producing microorganisms allows for their use in the production of pharmaceutical antibiotic drugs. |
| first_indexed | 2024-12-23T10:17:27Z |
| format | Article |
| id | doaj.art-1f7d1ea9a543484ca0c756c41266f43e |
| institution | Directory Open Access Journal |
| issn | 2308-4057 2310-9599 |
| language | English |
| last_indexed | 2024-12-23T10:17:27Z |
| publishDate | 2020-10-01 |
| publisher | Kemerovo State University |
| record_format | Article |
| series | Foods and Raw Materials |
| spelling | doaj.art-1f7d1ea9a543484ca0c756c41266f43e2022-12-21T17:50:46ZengKemerovo State UniversityFoods and Raw Materials2308-40572310-95992020-10-018237738410.21603/2308-4057-2020-2-377-384Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganismsYang Yong 0Babich Olga O. 1https://orcid.org/0000-0002-4921-8997Sukhikh Stanislav A. 2https://orcid.org/0000-0001-7910-8388Zimina Maria I. 3https://orcid.org/0000-0002-4622-8241Milentyeva Irina S. 4https://orcid.org/0000-0002-3536-562XQiqihar UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityKemerovo State UniversityIntroduction. Increased resistance of microorganisms to traditional antibiotics has created a practical need for isolating and synthesizing new antibiotics. We aimed to study the antibiotic activity and resistance of bacteriocins produced by lactic acid bacteria and other microorganisms. Study objects and methods. We studied the isolates of the following microorganism strains: Bacillus subtilis, Penicillium glabrum, Penicillium lagena, Pseudomonas koreenis, Penicillium ochrochloron, Leuconostoc lactis, Lactobacillus plantarum, Leuconostoc mesenteroides, Pediococcus acidilactici, Leuconostoc mesenteroides, Pediococcus pentosaceus, Lactobacillus casei, Lactobacillus fermentum, Bacteroides hypermegas, Bacteroides ruminicola, Pediococcus damnosus, Bacteroides paurosaccharolyticus, Halobacillus profundi, Geobacillus stearothermophilus, and Bacillus caldotenax. Pathogenic test strains included Escherichia coli, Salmonella enterica, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus mycoides, Alcaligenes faecalis, and Proteus vulgaris. The titer of microorganisms was determined by optical density measurements at 595 nm. Results and discussion. We found that eleven microorganisms out of twenty showed high antimicrobial activity against all test strains of pathogenic and opportunistic microorganisms. All the Bacteroides strains exhibited little antimicrobial activity against Gramnegative test strains, while Halobacillus profundi had an inhibitory effect on Gram-positive species only. The Penicillium strains also displayed a slight antimicrobial effect on pathogenic test strains. Conclusion. The antibiotic resistance of the studied lactic acid bacteria and other bacteriocin-producing microorganisms allows for their use in the production of pharmaceutical antibiotic drugs.http://jfrm.ru/files/archive/16/Yang.pdflactic acid bacteriabacteriocinsantibiotic propertiesantibiotic resistancenatural sourcesisolates |
| spellingShingle | Yang Yong Babich Olga O. Sukhikh Stanislav A. Zimina Maria I. Milentyeva Irina S. Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms Foods and Raw Materials lactic acid bacteria bacteriocins antibiotic properties antibiotic resistance natural sources isolates |
| title | Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms |
| title_full | Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms |
| title_fullStr | Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms |
| title_full_unstemmed | Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms |
| title_short | Antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin-producing microorganisms |
| title_sort | antibiotic activity and resistance of lactic acid bacteria and other antagonistic bacteriocin producing microorganisms |
| topic | lactic acid bacteria bacteriocins antibiotic properties antibiotic resistance natural sources isolates |
| url | http://jfrm.ru/files/archive/16/Yang.pdf |
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