Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease
Background Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm‐born infants, especially endothelial colony‐forming cells (ECFC), show enhanced susceptibi...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.009720 |
| _version_ | 1818328057257132032 |
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| author | Mariane Bertagnolli Li Feng Xie Katryn Paquette Ying He Anik Cloutier Rafael Oliveira Fernandes Chanel Béland Megan R. Sutherland Jacques Delfrate Daniel Curnier Jean‐Luc Bigras Alain Rivard Bernard Thébaud Thuy Mai Luu Anne Monique Nuyt |
| author_facet | Mariane Bertagnolli Li Feng Xie Katryn Paquette Ying He Anik Cloutier Rafael Oliveira Fernandes Chanel Béland Megan R. Sutherland Jacques Delfrate Daniel Curnier Jean‐Luc Bigras Alain Rivard Bernard Thébaud Thuy Mai Luu Anne Monique Nuyt |
| author_sort | Mariane Bertagnolli |
| collection | DOAJ |
| description | Background Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm‐born infants, especially endothelial colony‐forming cells (ECFC), show enhanced susceptibility to prematurity‐related pro‐oxidant stress. Whether ECFC dysfunction is present in adulthood following preterm birth is unknown. Methods and Results This cross‐sectional observational study includes 55 preterm‐born (≤29 gestational weeks) young adults (18–29 years old, 38% male) and 55 sex‐ and age‐matched full‐term controls. ECFC were isolated from peripheral blood; cell proliferative and vascular cord formation capacities were assessed in vitro. Daytime systolic blood pressure was higher, whereas glucose tolerance and body mass index were lower in preterm‐born subjects. ECFC colonies grew in culture for 62% of full‐term‐ and 58% of preterm‐born participants. Preterm‐born participants have formed ECFC colonies later in culture and have reduced proliferation compared with controls. Only in preterm‐born individuals, we observed that the later the ECFC colony grows in culture, the worse was overall ECFC function. In addition, in preterms, elevated systolic blood pressure significantly correlated with reduced ECFC proliferation (rS=−0.463; P=0.030) and numbers of branches formed on matrigel (rS=−0.443; P=0.039). In preterm‐born subjects, bronchopulmonary dysplasia was associated with impaired ECFC function, whereas exposure to antenatal steroids related to better ECFC function. Conclusions This study is the first to examine ECFC in preterm‐born adults and to demonstrate ECFC dysfunction compared with full‐term controls. In the preterm‐born group, ECFC dysfunction was associated with bronchopulmonary dysplasia, the major prematurity‐related neonatal morbidity, and with increased systolic blood pressure into adulthood. |
| first_indexed | 2024-12-13T12:26:06Z |
| format | Article |
| id | doaj.art-1f7df4b513c84d9381bf707956f74d06 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:26:06Z |
| publishDate | 2018-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-1f7df4b513c84d9381bf707956f74d062022-12-21T23:46:17ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-07-0171410.1161/JAHA.118.009720Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular DiseaseMariane Bertagnolli0Li Feng Xie1Katryn Paquette2Ying He3Anik Cloutier4Rafael Oliveira Fernandes5Chanel Béland6Megan R. Sutherland7Jacques Delfrate8Daniel Curnier9Jean‐Luc Bigras10Alain Rivard11Bernard Thébaud12Thuy Mai Luu13Anne Monique Nuyt14Sainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaDivision of Cardiology Department of Medicine CHUM Research Center Montréal CanadaDepartment of Pediatrics Ottawa Hospital Research Institute University of Ottawa Ontario CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaSainte‐Justine University Hospital Research Center Université de Montréal Quebec CanadaBackground Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm‐born infants, especially endothelial colony‐forming cells (ECFC), show enhanced susceptibility to prematurity‐related pro‐oxidant stress. Whether ECFC dysfunction is present in adulthood following preterm birth is unknown. Methods and Results This cross‐sectional observational study includes 55 preterm‐born (≤29 gestational weeks) young adults (18–29 years old, 38% male) and 55 sex‐ and age‐matched full‐term controls. ECFC were isolated from peripheral blood; cell proliferative and vascular cord formation capacities were assessed in vitro. Daytime systolic blood pressure was higher, whereas glucose tolerance and body mass index were lower in preterm‐born subjects. ECFC colonies grew in culture for 62% of full‐term‐ and 58% of preterm‐born participants. Preterm‐born participants have formed ECFC colonies later in culture and have reduced proliferation compared with controls. Only in preterm‐born individuals, we observed that the later the ECFC colony grows in culture, the worse was overall ECFC function. In addition, in preterms, elevated systolic blood pressure significantly correlated with reduced ECFC proliferation (rS=−0.463; P=0.030) and numbers of branches formed on matrigel (rS=−0.443; P=0.039). In preterm‐born subjects, bronchopulmonary dysplasia was associated with impaired ECFC function, whereas exposure to antenatal steroids related to better ECFC function. Conclusions This study is the first to examine ECFC in preterm‐born adults and to demonstrate ECFC dysfunction compared with full‐term controls. In the preterm‐born group, ECFC dysfunction was associated with bronchopulmonary dysplasia, the major prematurity‐related neonatal morbidity, and with increased systolic blood pressure into adulthood.https://www.ahajournals.org/doi/10.1161/JAHA.118.009720bronchopulmonary dysplasiacardiovascular disease risk factorsendothelial progenitor cellshypertensionpregnancy and postpartumpreterm birth |
| spellingShingle | Mariane Bertagnolli Li Feng Xie Katryn Paquette Ying He Anik Cloutier Rafael Oliveira Fernandes Chanel Béland Megan R. Sutherland Jacques Delfrate Daniel Curnier Jean‐Luc Bigras Alain Rivard Bernard Thébaud Thuy Mai Luu Anne Monique Nuyt Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease bronchopulmonary dysplasia cardiovascular disease risk factors endothelial progenitor cells hypertension pregnancy and postpartum preterm birth |
| title | Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease |
| title_full | Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease |
| title_fullStr | Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease |
| title_full_unstemmed | Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease |
| title_short | Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease |
| title_sort | endothelial colony forming cells in young adults born preterm a novel link between neonatal complications and adult risks for cardiovascular disease |
| topic | bronchopulmonary dysplasia cardiovascular disease risk factors endothelial progenitor cells hypertension pregnancy and postpartum preterm birth |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.009720 |
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