Tapentadol extended release for the management of chronic neck pain
Domenico Billeci,1 Flaminia Coluzzi2 1Division of Neurosurgery, Ca’Foncello Hospital, University of Padova, Treviso, 2Department of Medical and Surgical Sciences and Biotechnologies, Unit of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, Faculty of Pharmacy and Medicine, Sapie...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-03-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/tapentadol-extended-release-for-the-management-of-chronic-neck-pain-peer-reviewed-article-JPR |
| _version_ | 1818617699593355264 |
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| author | Billeci D Coluzzi F |
| author_facet | Billeci D Coluzzi F |
| author_sort | Billeci D |
| collection | DOAJ |
| description | Domenico Billeci,1 Flaminia Coluzzi2 1Division of Neurosurgery, Ca’Foncello Hospital, University of Padova, Treviso, 2Department of Medical and Surgical Sciences and Biotechnologies, Unit of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy Background: The role of opioids in the management of chronic neck pain is still poorly investigated. No data are available on tapentadol extended release (ER). In this article, we present 54 patients with moderate-to-severe chronic neck pain treated with tapentadol ER. Patients and methods: Patients received tapentadol ER 100 mg/day; dosage was then adjusted according to clinical needs. The following parameters were recorded: pain; Douleur Neuropathique 4 score; Neck Disability Index score; range of motion; pain-associated sleep interference; quality of life (Short Form [36] Health Survey); Patient Global Impression of Change (PGIC); Clinician GIC; opioid-related adverse effects; and need for other analgesics. Results: A total of 44 of 54 patients completed the 12-week observation. Tapentadol ER daily doses increased from 100 mg/day to a mean (standard deviation) dosage of 204.5 (102.8) mg/day at the final evaluation. Mean pain intensity at movement significantly decreased from baseline (8.1 [1.1]) to all time points (P<0.01). At baseline, 70% of patients presented a positive neuropathic component. This percentage dropped to 23% after 12 weeks. Tapentadol improved Neck Disability Index scores from 55.6 (18.6) at baseline to 19.7 (20.9) at the final evaluation (P<0.01). Tapentadol significantly improved neck range of motion in all three planes of motion, particularly in lateral flexion. Quality of life significantly improved in all Short Form (36) Health Survey subscales (P<0.01) and in both physical and mental status (P<0.01). Based on PGIC results, approximately 90% of patients rated their overall condition as much/very much improved. Tapentadol was well tolerated: no patients discontinued due to side effects. The use of other analgesics was reduced during the observed period. Conclusion: Our results suggest that tapentadol ER, started at 100 mg/day, is effective and well tolerated in patients with moderate-to-severe chronic neck pain, including opioid-naïve subjects. Patients can expect a decrease in pain, an improvement in neck function, and a decrease in neuropathic symptoms. Keywords: tapentadol, chronic neck pain, neuropathic pain, opioids, Neck Disability Index, range of motion |
| first_indexed | 2024-12-16T17:09:51Z |
| format | Article |
| id | doaj.art-1f7e6be0ee2041abb99b4fc434246944 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-16T17:09:51Z |
| publishDate | 2017-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-1f7e6be0ee2041abb99b4fc4342469442022-12-21T22:23:27ZengDove Medical PressJournal of Pain Research1178-70902017-03-01Volume 1049550531654Tapentadol extended release for the management of chronic neck painBilleci DColuzzi FDomenico Billeci,1 Flaminia Coluzzi2 1Division of Neurosurgery, Ca’Foncello Hospital, University of Padova, Treviso, 2Department of Medical and Surgical Sciences and Biotechnologies, Unit of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Latina, Italy Background: The role of opioids in the management of chronic neck pain is still poorly investigated. No data are available on tapentadol extended release (ER). In this article, we present 54 patients with moderate-to-severe chronic neck pain treated with tapentadol ER. Patients and methods: Patients received tapentadol ER 100 mg/day; dosage was then adjusted according to clinical needs. The following parameters were recorded: pain; Douleur Neuropathique 4 score; Neck Disability Index score; range of motion; pain-associated sleep interference; quality of life (Short Form [36] Health Survey); Patient Global Impression of Change (PGIC); Clinician GIC; opioid-related adverse effects; and need for other analgesics. Results: A total of 44 of 54 patients completed the 12-week observation. Tapentadol ER daily doses increased from 100 mg/day to a mean (standard deviation) dosage of 204.5 (102.8) mg/day at the final evaluation. Mean pain intensity at movement significantly decreased from baseline (8.1 [1.1]) to all time points (P<0.01). At baseline, 70% of patients presented a positive neuropathic component. This percentage dropped to 23% after 12 weeks. Tapentadol improved Neck Disability Index scores from 55.6 (18.6) at baseline to 19.7 (20.9) at the final evaluation (P<0.01). Tapentadol significantly improved neck range of motion in all three planes of motion, particularly in lateral flexion. Quality of life significantly improved in all Short Form (36) Health Survey subscales (P<0.01) and in both physical and mental status (P<0.01). Based on PGIC results, approximately 90% of patients rated their overall condition as much/very much improved. Tapentadol was well tolerated: no patients discontinued due to side effects. The use of other analgesics was reduced during the observed period. Conclusion: Our results suggest that tapentadol ER, started at 100 mg/day, is effective and well tolerated in patients with moderate-to-severe chronic neck pain, including opioid-naïve subjects. Patients can expect a decrease in pain, an improvement in neck function, and a decrease in neuropathic symptoms. Keywords: tapentadol, chronic neck pain, neuropathic pain, opioids, Neck Disability Index, range of motionhttps://www.dovepress.com/tapentadol-extended-release-for-the-management-of-chronic-neck-pain-peer-reviewed-article-JPRTapentadolChronic neck painNeuropathic painOpioidsNeck Disability IndexRange of Motion |
| spellingShingle | Billeci D Coluzzi F Tapentadol extended release for the management of chronic neck pain Journal of Pain Research Tapentadol Chronic neck pain Neuropathic pain Opioids Neck Disability Index Range of Motion |
| title | Tapentadol extended release for the management of chronic neck pain |
| title_full | Tapentadol extended release for the management of chronic neck pain |
| title_fullStr | Tapentadol extended release for the management of chronic neck pain |
| title_full_unstemmed | Tapentadol extended release for the management of chronic neck pain |
| title_short | Tapentadol extended release for the management of chronic neck pain |
| title_sort | tapentadol extended release for the management of chronic neck pain |
| topic | Tapentadol Chronic neck pain Neuropathic pain Opioids Neck Disability Index Range of Motion |
| url | https://www.dovepress.com/tapentadol-extended-release-for-the-management-of-chronic-neck-pain-peer-reviewed-article-JPR |
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