Correlation between overall survival and quality of life in colon cancer patients with chemotherapy
Abstract Background Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL). As data on objective ind...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-10989-x |
| _version_ | 1797811389312532480 |
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| author | Yasuko Murakawa Kazunori Ootsuka Jun Kusaka Kou Miura |
| author_facet | Yasuko Murakawa Kazunori Ootsuka Jun Kusaka Kou Miura |
| author_sort | Yasuko Murakawa |
| collection | DOAJ |
| description | Abstract Background Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL). As data on objective indicators of QOL in cancer patients, such as length of hospitalisation (LOH), outpatient consultation times (OCT), and hospital-free survival (HFS), is limited, this study compared ICF and ICR with respect to OS and QOL over the entire clinical course. Methods We retrospectively evaluated 90 inoperable colon cancer patients with chemotherapy and compared ICF and ICR in terms of OS, LOH, OCT, and HFS. Results Patients with ICF had a worse OS than those with ICR. In patients with ICF and ICR, OS and LOH were not correlated but OS and OCT and OS and HFS were strongly correlated. In patients with ICF and ICR, OCT and HFS accounted for approximately 8% and 90% of their OS, respectively. Conclusions The LOH, OCT, and HFS are important factors for evaluating objective QOL of patients with inoperable colon cancer and should be considered when making treatment decisions. |
| first_indexed | 2024-03-13T07:22:58Z |
| format | Article |
| id | doaj.art-1f7f6e3ef7cd4e068b5a659d63549ddd |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-13T07:22:58Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-1f7f6e3ef7cd4e068b5a659d63549ddd2023-06-04T11:31:12ZengBMCBMC Cancer1471-24072023-05-012311710.1186/s12885-023-10989-xCorrelation between overall survival and quality of life in colon cancer patients with chemotherapyYasuko Murakawa0Kazunori Ootsuka1Jun Kusaka2Kou Miura3Department of Cancer Chemotherapy, Miyagi Cancer CenterDepartment of Cancer Chemotherapy, Miyagi Cancer CenterDepartment of Gastroenterology, Miyagi Cancer CenterDepartment of Digestive Surgery, Miyagi Cancer CenterAbstract Background Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL). As data on objective indicators of QOL in cancer patients, such as length of hospitalisation (LOH), outpatient consultation times (OCT), and hospital-free survival (HFS), is limited, this study compared ICF and ICR with respect to OS and QOL over the entire clinical course. Methods We retrospectively evaluated 90 inoperable colon cancer patients with chemotherapy and compared ICF and ICR in terms of OS, LOH, OCT, and HFS. Results Patients with ICF had a worse OS than those with ICR. In patients with ICF and ICR, OS and LOH were not correlated but OS and OCT and OS and HFS were strongly correlated. In patients with ICF and ICR, OCT and HFS accounted for approximately 8% and 90% of their OS, respectively. Conclusions The LOH, OCT, and HFS are important factors for evaluating objective QOL of patients with inoperable colon cancer and should be considered when making treatment decisions.https://doi.org/10.1186/s12885-023-10989-xChemotherapyHospitalisationInoperable colon cancerOutpatient consultationOverall survivalQuality of life |
| spellingShingle | Yasuko Murakawa Kazunori Ootsuka Jun Kusaka Kou Miura Correlation between overall survival and quality of life in colon cancer patients with chemotherapy BMC Cancer Chemotherapy Hospitalisation Inoperable colon cancer Outpatient consultation Overall survival Quality of life |
| title | Correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| title_full | Correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| title_fullStr | Correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| title_full_unstemmed | Correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| title_short | Correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| title_sort | correlation between overall survival and quality of life in colon cancer patients with chemotherapy |
| topic | Chemotherapy Hospitalisation Inoperable colon cancer Outpatient consultation Overall survival Quality of life |
| url | https://doi.org/10.1186/s12885-023-10989-x |
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