Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial
The aim of this study was to evaluate the efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) in adults with white blood cells between 3 and 8 × 103 cells/µL by assessing natural killer (NK) cell activity and immune-related biomarkers. Overall, 100 participants (CAEC group...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620304837 |
| _version_ | 1819292842641588224 |
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| author | Yee Ran Lyu Sol-ji Jung Su-Won Lee Won-Kyung Yang Seung-Hyung Kim In Chul Jung Kun-Hoae Kim Han-Young Kim Yun Jeong Yang Yunhee Lee Suk Ran Yoon Yang-Chun Park |
| author_facet | Yee Ran Lyu Sol-ji Jung Su-Won Lee Won-Kyung Yang Seung-Hyung Kim In Chul Jung Kun-Hoae Kim Han-Young Kim Yun Jeong Yang Yunhee Lee Suk Ran Yoon Yang-Chun Park |
| author_sort | Yee Ran Lyu |
| collection | DOAJ |
| description | The aim of this study was to evaluate the efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) in adults with white blood cells between 3 and 8 × 103 cells/µL by assessing natural killer (NK) cell activity and immune-related biomarkers. Overall, 100 participants (CAEC group = 50, placebo group = 50) were randomised, and administered CAEC or placebo once daily for 8 weeks, with an evaluation visit performed every 4 weeks. NK cell activity, the primary outcome, significantly increased in CAEC when compared with the placebo at effector-to-target (E:T) ratios of 25:1 and 50:1 after 8 weeks. Compared with the placebo group, IL-10 demonstrated significant differences at week 8 in the CAEC group. Our findings demonstrate that CAEC is safe and enhances immune function by stimulating NK cell activity through IL-10 expression. Hence, we anticipate that CAEC can be developed as a functional food for stimulating immunity. |
| first_indexed | 2024-12-24T04:00:58Z |
| format | Article |
| id | doaj.art-1f7f814d88894b889e05a44a6a52dcf9 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:00:58Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1f7f814d88894b889e05a44a6a52dcf92022-12-21T17:16:19ZengElsevierJournal of Functional Foods1756-46462020-12-0175104259Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trialYee Ran Lyu0Sol-ji Jung1Su-Won Lee2Won-Kyung Yang3Seung-Hyung Kim4In Chul Jung5Kun-Hoae Kim6Han-Young Kim7Yun Jeong Yang8Yunhee Lee9Suk Ran Yoon10Yang-Chun Park11Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of KoreaDivision of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of KoreaDivision of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea; Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of KoreaInstitute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of KoreaDepartment of Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon, Republic of KoreaCentral Research Laboratories of Aekyung Industrial Co. Ltd., Daejeon, Republic of KoreaCentral Research Laboratories of Aekyung Industrial Co. Ltd., Daejeon, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biochemistry, College of Pharmacy, Chungnam National University, Daejeon, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biochemistry, College of Pharmacy, Chungnam National University, Daejeon, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Corresponding authors at: Department of Korean Internal Medicine, College of Korean Medicine, Daejeon University, 62, Daeha-ro, Dong-gu, Daejeon 34520, Republic of Korea (Y.-C. Park). Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 125, Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea (S.R. Yoon).Division of Respiratory Medicine, Dept. of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea; Corresponding authors at: Department of Korean Internal Medicine, College of Korean Medicine, Daejeon University, 62, Daeha-ro, Dong-gu, Daejeon 34520, Republic of Korea (Y.-C. Park). Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 125, Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea (S.R. Yoon).The aim of this study was to evaluate the efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) in adults with white blood cells between 3 and 8 × 103 cells/µL by assessing natural killer (NK) cell activity and immune-related biomarkers. Overall, 100 participants (CAEC group = 50, placebo group = 50) were randomised, and administered CAEC or placebo once daily for 8 weeks, with an evaluation visit performed every 4 weeks. NK cell activity, the primary outcome, significantly increased in CAEC when compared with the placebo at effector-to-target (E:T) ratios of 25:1 and 50:1 after 8 weeks. Compared with the placebo group, IL-10 demonstrated significant differences at week 8 in the CAEC group. Our findings demonstrate that CAEC is safe and enhances immune function by stimulating NK cell activity through IL-10 expression. Hence, we anticipate that CAEC can be developed as a functional food for stimulating immunity.http://www.sciencedirect.com/science/article/pii/S1756464620304837Immune functionCAECCanavalia gladiateArctium lappaFunctional food |
| spellingShingle | Yee Ran Lyu Sol-ji Jung Su-Won Lee Won-Kyung Yang Seung-Hyung Kim In Chul Jung Kun-Hoae Kim Han-Young Kim Yun Jeong Yang Yunhee Lee Suk Ran Yoon Yang-Chun Park Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial Journal of Functional Foods Immune function CAEC Canavalia gladiate Arctium lappa Functional food |
| title | Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial |
| title_full | Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial |
| title_fullStr | Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial |
| title_full_unstemmed | Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial |
| title_short | Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial |
| title_sort | efficacy and safety of caec canavalia gladiata arctium lappa extract complex on immune function enhancement an 8 week randomised double blind placebo controlled clinical trial |
| topic | Immune function CAEC Canavalia gladiate Arctium lappa Functional food |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620304837 |
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