Thymomas With Intravascular and Intracardiac Growth
Thymomas are derived from the epithelial component of the thymus and constitute the most common tumor of the anterior mediastinum. These neoplasms are considered malignant for their potential for invasion and metastases. Several histopathologic subclassification schemes have been proposed over the y...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.881553/full |
| _version_ | 1811343192870617088 |
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| author | Andrea Valeria Arrossi Josephine K. Dermawan Michael Bolen Daniel Raymond |
| author_facet | Andrea Valeria Arrossi Josephine K. Dermawan Michael Bolen Daniel Raymond |
| author_sort | Andrea Valeria Arrossi |
| collection | DOAJ |
| description | Thymomas are derived from the epithelial component of the thymus and constitute the most common tumor of the anterior mediastinum. These neoplasms are considered malignant for their potential for invasion and metastases. Several histopathologic subclassification schemes have been proposed over the years, however, correlation of histotypes with prognosis remains controversial. In contrast, studies invariably have shown that staging and resection status correlate with oncologic behavior and disease outcomes. In this regard, several staging systems have been presented, though transcapsular invasion and degree of involvement of adjacent anatomic structures are common denominators of all schemes. Involvement of the great vessels and heart most commonly results from direct invasion, which may lead to unusual clinical presentations such as superior vena cava syndrome. Moreover, intravascular and intracardiac growth with or without direct mural invasion rarely occurs. We provide an overview of thymomas with intravascular and intracardiac involvement. |
| first_indexed | 2024-04-13T19:24:15Z |
| format | Article |
| id | doaj.art-1f7f885f92b9460eb2fdef2a76c0fded |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T19:24:15Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1f7f885f92b9460eb2fdef2a76c0fded2022-12-22T02:33:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.881553881553Thymomas With Intravascular and Intracardiac GrowthAndrea Valeria Arrossi0Josephine K. Dermawan1Michael Bolen2Daniel Raymond3Department of Pathology, Robert J. (R.J) Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United StatesDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesImaging Institute, Cardiovascular and Thoracic Radiology, Cleveland Clinic, Cleveland, OH, United StatesDepartment of Thoracic Surgery, Cleveland Clinic, Cleveland, OH, United StatesThymomas are derived from the epithelial component of the thymus and constitute the most common tumor of the anterior mediastinum. These neoplasms are considered malignant for their potential for invasion and metastases. Several histopathologic subclassification schemes have been proposed over the years, however, correlation of histotypes with prognosis remains controversial. In contrast, studies invariably have shown that staging and resection status correlate with oncologic behavior and disease outcomes. In this regard, several staging systems have been presented, though transcapsular invasion and degree of involvement of adjacent anatomic structures are common denominators of all schemes. Involvement of the great vessels and heart most commonly results from direct invasion, which may lead to unusual clinical presentations such as superior vena cava syndrome. Moreover, intravascular and intracardiac growth with or without direct mural invasion rarely occurs. We provide an overview of thymomas with intravascular and intracardiac involvement.https://www.frontiersin.org/articles/10.3389/fonc.2022.881553/fullinvasive thymomastagingintravascular growthsuperior vena cava syndromeintravascular growth pattern |
| spellingShingle | Andrea Valeria Arrossi Josephine K. Dermawan Michael Bolen Daniel Raymond Thymomas With Intravascular and Intracardiac Growth Frontiers in Oncology invasive thymoma staging intravascular growth superior vena cava syndrome intravascular growth pattern |
| title | Thymomas With Intravascular and Intracardiac Growth |
| title_full | Thymomas With Intravascular and Intracardiac Growth |
| title_fullStr | Thymomas With Intravascular and Intracardiac Growth |
| title_full_unstemmed | Thymomas With Intravascular and Intracardiac Growth |
| title_short | Thymomas With Intravascular and Intracardiac Growth |
| title_sort | thymomas with intravascular and intracardiac growth |
| topic | invasive thymoma staging intravascular growth superior vena cava syndrome intravascular growth pattern |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.881553/full |
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