Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis
Bovine Pestiviruses A and B, formerly known as bovine viral diarrhoea viruses (BVDV)-1 and 2, respectively, are important pathogens of cattle worldwide, responsible for significant economic losses. Bovine viral diarrhoea control programmes are in effect in several high-income countries but less so i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/10/1134 |
| _version_ | 1827704741448122368 |
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| author | Victor Riitho Rebecca Strong Magdalena Larska Simon P. Graham Falko Steinbach |
| author_facet | Victor Riitho Rebecca Strong Magdalena Larska Simon P. Graham Falko Steinbach |
| author_sort | Victor Riitho |
| collection | DOAJ |
| description | Bovine Pestiviruses A and B, formerly known as bovine viral diarrhoea viruses (BVDV)-1 and 2, respectively, are important pathogens of cattle worldwide, responsible for significant economic losses. Bovine viral diarrhoea control programmes are in effect in several high-income countries but less so in low- and middle-income countries where bovine pestiviruses are not considered in disease control programmes. However, bovine pestiviruses are genetically and antigenically diverse, which affects the efficiency of the control programmes. The emergence of atypical ruminant pestiviruses (Pestivirus H or BVDV-3) from various parts of the world and the detection of Pestivirus D (border disease virus) in cattle highlights the challenge that pestiviruses continue to pose to control measures including the development of vaccines with improved cross-protective potential and enhanced diagnostics. This review examines the effect of bovine pestivirus diversity and emergence of atypical pestiviruses in disease control by vaccination and diagnosis. |
| first_indexed | 2024-03-10T15:48:29Z |
| format | Article |
| id | doaj.art-1f802de8d19741668b0f8f9d548fef33 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T15:48:29Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-1f802de8d19741668b0f8f9d548fef332023-11-20T16:13:35ZengMDPI AGViruses1999-49152020-10-011210113410.3390/v12101134Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and DiagnosisVictor Riitho0Rebecca Strong1Magdalena Larska2Simon P. Graham3Falko Steinbach4Virology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UKVirology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UKDepartment of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, PolandThe Pirbright Institute, Ash Road, Pirbright GU24 0NF, UKVirology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UKBovine Pestiviruses A and B, formerly known as bovine viral diarrhoea viruses (BVDV)-1 and 2, respectively, are important pathogens of cattle worldwide, responsible for significant economic losses. Bovine viral diarrhoea control programmes are in effect in several high-income countries but less so in low- and middle-income countries where bovine pestiviruses are not considered in disease control programmes. However, bovine pestiviruses are genetically and antigenically diverse, which affects the efficiency of the control programmes. The emergence of atypical ruminant pestiviruses (Pestivirus H or BVDV-3) from various parts of the world and the detection of Pestivirus D (border disease virus) in cattle highlights the challenge that pestiviruses continue to pose to control measures including the development of vaccines with improved cross-protective potential and enhanced diagnostics. This review examines the effect of bovine pestivirus diversity and emergence of atypical pestiviruses in disease control by vaccination and diagnosis.https://www.mdpi.com/1999-4915/12/10/1134bovine pestivirusesbovine viral diarrhoeavaccinationcontroldiagnosisantigenic cross-reactivity |
| spellingShingle | Victor Riitho Rebecca Strong Magdalena Larska Simon P. Graham Falko Steinbach Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis Viruses bovine pestiviruses bovine viral diarrhoea vaccination control diagnosis antigenic cross-reactivity |
| title | Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis |
| title_full | Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis |
| title_fullStr | Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis |
| title_full_unstemmed | Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis |
| title_short | Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis |
| title_sort | bovine pestivirus heterogeneity and its potential impact on vaccination and diagnosis |
| topic | bovine pestiviruses bovine viral diarrhoea vaccination control diagnosis antigenic cross-reactivity |
| url | https://www.mdpi.com/1999-4915/12/10/1134 |
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