Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer
Despite the significant improvement in the treatment modalities, cancer is one of the fastest-growing chronic disease conditions all over the world. Genetic and Epigenetic alterations in the normal physiology of the cell are the key factor for tumor development. These changes can trigger the product...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2023-07-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-13-483.pdf |
| _version_ | 1797673420270338048 |
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| author | Bhagyalakshmi Nair Anisha Kuriakose Bilha Baby Lekshmi.R. Nath |
| author_facet | Bhagyalakshmi Nair Anisha Kuriakose Bilha Baby Lekshmi.R. Nath |
| author_sort | Bhagyalakshmi Nair |
| collection | DOAJ |
| description | Despite the significant improvement in the treatment modalities, cancer is one of the fastest-growing chronic disease conditions all over the world. Genetic and Epigenetic alterations in the normal physiology of the cell are the key factor for tumor development. These changes can trigger the production of abnormal protein expressions through stimulation of different signaling pathways and can deeply affect normal cell growth and proliferation. Any altered protein expression, genetic variation, micro-RNA or post-translational protein modifications that indicate tumorigenesis can act as an early signal termed as biomarker. Cancer, being a multistep process with accumulating genetic and epigenetic alterations, could be detected early with suitable biomarkers. There are several proteins such as AFP, CA-125, PSA, troponin, CEA, osteopontin, CA 19-9 that act as biomarkers which help in early detection, prognosis, and monitoring of disease progression, a hunt for newer biomarkers with higher specificity and sensitivity is still ongoing. Tumor-specific growth factor (TSGF) is one such budding and prevailing tumor biomarker used for the early-stage detection of several types of carcinomas. TSGF is a gene that helps in tumor angiogenesis and gets released during the preliminary stages from cancer cells that ensure the vascular proliferation of the same. In this review, the clinical investigations of TSGF in different kinds of malignancy is discussed in detail and suggests the possibility of using TSGF as a biomarker in early diagnosis of cancer. |
| first_indexed | 2024-03-11T21:44:17Z |
| format | Article |
| id | doaj.art-1f822d344db049eba949e6a7908ec463 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-03-11T21:44:17Z |
| publishDate | 2023-07-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-1f822d344db049eba949e6a7908ec4632023-09-26T10:42:23ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082023-07-0113348348810.34172/apb.2023.051apb-33078Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of CancerBhagyalakshmi Nair0Anisha Kuriakose1Bilha Baby2Lekshmi.R. Nath3Department of Pharmacognosy, Amrita School of Pharmacy, Amrita VishwaVidyapeetham, AIMS Health Science Campus, Ponekkara P.O., Kochi, Kerala 682041, India.Department of Pharmacognosy, Amrita School of Pharmacy, Amrita VishwaVidyapeetham, AIMS Health Science Campus, Ponekkara P.O., Kochi, Kerala 682041, India.Department of Pharmacognosy, Amrita School of Pharmacy, Amrita VishwaVidyapeetham, AIMS Health Science Campus, Ponekkara P.O., Kochi, Kerala 682041, India.Department of Pharmacognosy, Amrita School of Pharmacy, Amrita VishwaVidyapeetham, AIMS Health Science Campus, Ponekkara P.O., Kochi, Kerala 682041, India.Despite the significant improvement in the treatment modalities, cancer is one of the fastest-growing chronic disease conditions all over the world. Genetic and Epigenetic alterations in the normal physiology of the cell are the key factor for tumor development. These changes can trigger the production of abnormal protein expressions through stimulation of different signaling pathways and can deeply affect normal cell growth and proliferation. Any altered protein expression, genetic variation, micro-RNA or post-translational protein modifications that indicate tumorigenesis can act as an early signal termed as biomarker. Cancer, being a multistep process with accumulating genetic and epigenetic alterations, could be detected early with suitable biomarkers. There are several proteins such as AFP, CA-125, PSA, troponin, CEA, osteopontin, CA 19-9 that act as biomarkers which help in early detection, prognosis, and monitoring of disease progression, a hunt for newer biomarkers with higher specificity and sensitivity is still ongoing. Tumor-specific growth factor (TSGF) is one such budding and prevailing tumor biomarker used for the early-stage detection of several types of carcinomas. TSGF is a gene that helps in tumor angiogenesis and gets released during the preliminary stages from cancer cells that ensure the vascular proliferation of the same. In this review, the clinical investigations of TSGF in different kinds of malignancy is discussed in detail and suggests the possibility of using TSGF as a biomarker in early diagnosis of cancer.https://apb.tbzmed.ac.ir/PDF/apb-13-483.pdfbiomarkercancerclinical implicationsdiagnosistumor-specific growth factor |
| spellingShingle | Bhagyalakshmi Nair Anisha Kuriakose Bilha Baby Lekshmi.R. Nath Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer Advanced Pharmaceutical Bulletin biomarker cancer clinical implications diagnosis tumor-specific growth factor |
| title | Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer |
| title_full | Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer |
| title_fullStr | Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer |
| title_full_unstemmed | Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer |
| title_short | Tumor-Specific Growth Factor (TSGF): A Futuristic Tumor Biomarker in Early Diagnosis of Cancer |
| title_sort | tumor specific growth factor tsgf a futuristic tumor biomarker in early diagnosis of cancer |
| topic | biomarker cancer clinical implications diagnosis tumor-specific growth factor |
| url | https://apb.tbzmed.ac.ir/PDF/apb-13-483.pdf |
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