First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy
Online proton range verification is a rapidly emerging field characterised by its ability to reduce the error margins during proton beam therapy, as it is patient-specific and in vivo. In particular, secondary prompt gamma detection is a promising tool to monitor the dose delivery. The present resea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/13/7735 |
| _version_ | 1797592110838317056 |
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| author | Maria L. Perez-Lara Jia C. Khong Matthew D. Wilson Ben D. Cline Robert M. Moss |
| author_facet | Maria L. Perez-Lara Jia C. Khong Matthew D. Wilson Ben D. Cline Robert M. Moss |
| author_sort | Maria L. Perez-Lara |
| collection | DOAJ |
| description | Online proton range verification is a rapidly emerging field characterised by its ability to reduce the error margins during proton beam therapy, as it is patient-specific and in vivo. In particular, secondary prompt gamma detection is a promising tool to monitor the dose delivery. The present research evaluates the capability of a HEXITEC detector to identify the prompt gammas produced during proton beam therapy, and assesses its potential for online range verification. To achieve this, the detector is placed at one side of a water phantom, which is irradiated at different proton energies in the University College London Hospital Proton Centre. For further analysis, Monte Carlo simulations are performed using Geant4 and the same geometry as the experiment. The results show that HEXITEC has the potential to be part of a detection system that could identify secondary prompt gammas within the secondary field produced inside the target, allowing for the in-detector discrimination of these particles via cluster size analysis. The comparison between data sets shows that there is a high level of accuracy between the model and the experimental measurements in terms of secondary flux and charge diffusion inside the detector, which poses the model as a fundamental tool for future optimisation studies. |
| first_indexed | 2024-03-11T01:46:49Z |
| format | Article |
| id | doaj.art-1f831917161d4b40854e86d600f387bb |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T01:46:49Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-1f831917161d4b40854e86d600f387bb2023-11-18T16:10:42ZengMDPI AGApplied Sciences2076-34172023-06-011313773510.3390/app13137735First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam TherapyMaria L. Perez-Lara0Jia C. Khong1Matthew D. Wilson2Ben D. Cline3Robert M. Moss4Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKDepartment of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKRutherford Appleton Laboratory in the Science and Technology Facilities Council, Chilton OX11 0QX, UKRutherford Appleton Laboratory in the Science and Technology Facilities Council, Chilton OX11 0QX, UKDepartment of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UKOnline proton range verification is a rapidly emerging field characterised by its ability to reduce the error margins during proton beam therapy, as it is patient-specific and in vivo. In particular, secondary prompt gamma detection is a promising tool to monitor the dose delivery. The present research evaluates the capability of a HEXITEC detector to identify the prompt gammas produced during proton beam therapy, and assesses its potential for online range verification. To achieve this, the detector is placed at one side of a water phantom, which is irradiated at different proton energies in the University College London Hospital Proton Centre. For further analysis, Monte Carlo simulations are performed using Geant4 and the same geometry as the experiment. The results show that HEXITEC has the potential to be part of a detection system that could identify secondary prompt gammas within the secondary field produced inside the target, allowing for the in-detector discrimination of these particles via cluster size analysis. The comparison between data sets shows that there is a high level of accuracy between the model and the experimental measurements in terms of secondary flux and charge diffusion inside the detector, which poses the model as a fundamental tool for future optimisation studies.https://www.mdpi.com/2076-3417/13/13/7735HEXITEC detectorGeant4proton beam therapyprompt gamma detectionproton range monitoring |
| spellingShingle | Maria L. Perez-Lara Jia C. Khong Matthew D. Wilson Ben D. Cline Robert M. Moss First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy Applied Sciences HEXITEC detector Geant4 proton beam therapy prompt gamma detection proton range monitoring |
| title | First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy |
| title_full | First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy |
| title_fullStr | First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy |
| title_full_unstemmed | First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy |
| title_short | First Study of a HEXITEC Detector for Secondary Particle Characterisation during Proton Beam Therapy |
| title_sort | first study of a hexitec detector for secondary particle characterisation during proton beam therapy |
| topic | HEXITEC detector Geant4 proton beam therapy prompt gamma detection proton range monitoring |
| url | https://www.mdpi.com/2076-3417/13/13/7735 |
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