Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection
Background/Aims Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods Patients were non-randomly divided into the follo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Gastrointestinal Endoscopy
2019-09-01
|
| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2018-152.pdf |
| _version_ | 1797428216687755264 |
|---|---|
| author | Eunju Jeong In kyung Yoo Ozlem Ozer Cakir Hee Kyung Kim Won Hee Kim Sung Pyo Hong Joo Young Cho |
| author_facet | Eunju Jeong In kyung Yoo Ozlem Ozer Cakir Hee Kyung Kim Won Hee Kim Sung Pyo Hong Joo Young Cho |
| author_sort | Eunju Jeong |
| collection | DOAJ |
| description | Background/Aims Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery). Results We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group. Conclusions The local injection of PRP is a safe and effective procedure for ulcer healing after ESD. |
| first_indexed | 2024-03-09T08:55:54Z |
| format | Article |
| id | doaj.art-1f851576fda24763a2a40c8cbca522f4 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T08:55:54Z |
| publishDate | 2019-09-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-1f851576fda24763a2a40c8cbca522f42023-12-02T13:00:55ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432019-09-0152547247810.5946/ce.2018.1527217Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal DissectionEunju Jeong0In kyung Yoo1Ozlem Ozer Cakir2Hee Kyung Kim3Won Hee Kim4Sung Pyo Hong5Joo Young Cho6 Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea Alanya Alaaddin Keykubat University, School of Medicine Department of Gastroenterology and Hepatology, Antalya, Turkey Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, KoreaBackground/Aims Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery). Results We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group. Conclusions The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.http://www.e-ce.org/upload/pdf/ce-2018-152.pdfEndoscopic submucosal dissectionPlatelet-rich plasmaUlcer healing |
| spellingShingle | Eunju Jeong In kyung Yoo Ozlem Ozer Cakir Hee Kyung Kim Won Hee Kim Sung Pyo Hong Joo Young Cho Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection Clinical Endoscopy Endoscopic submucosal dissection Platelet-rich plasma Ulcer healing |
| title | Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection |
| title_full | Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection |
| title_fullStr | Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection |
| title_full_unstemmed | Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection |
| title_short | Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection |
| title_sort | effectiveness of autologous platelet rich plasma for the healing of ulcers after endoscopic submucosal dissection |
| topic | Endoscopic submucosal dissection Platelet-rich plasma Ulcer healing |
| url | http://www.e-ce.org/upload/pdf/ce-2018-152.pdf |
| work_keys_str_mv | AT eunjujeong effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT inkyungyoo effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT ozlemozercakir effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT heekyungkim effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT wonheekim effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT sungpyohong effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection AT jooyoungcho effectivenessofautologousplateletrichplasmaforthehealingofulcersafterendoscopicsubmucosaldissection |