Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication)
Summary: It is not yet known why anti-resorptive agent-related osteonecrosis specifically affects the jaw. Here we assessed changes in the bone metabolism of the mandible in response to long-term bisphosphonate (BP) therapy, and we compared the bone metabolism changes of the mandible with those of o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Japanese Dental Science Review |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761618301029 |
| _version_ | 1819238338177007616 |
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| author | Yumiko Ohbayashi Fumi Nakai Akinori Iwasaki Takaaki Ogawa Yuka Yamamoto Yoshihiro Nishiyama Minoru Miyake |
| author_facet | Yumiko Ohbayashi Fumi Nakai Akinori Iwasaki Takaaki Ogawa Yuka Yamamoto Yoshihiro Nishiyama Minoru Miyake |
| author_sort | Yumiko Ohbayashi |
| collection | DOAJ |
| description | Summary: It is not yet known why anti-resorptive agent-related osteonecrosis specifically affects the jaw. Here we assessed changes in the bone metabolism of the mandible in response to long-term bisphosphonate (BP) therapy, and we compared the bone metabolism changes of the mandible with those of other bone sites using a quantitative analysis by bone scintigraphy. The region of interest was selected by identifying without an abnormal accumulation of the mandible, humerus, second and fourth lumbar vertebrae, iliac crest, intertrochanteric femur and diaphysis. Bone scintigraphy images were quantified using a value we termed the ‘bone uptake value (BUV)’. In the low-dose bisphosphonate (LBP) group (n = 21), the patients were undergoing osteoporosis treatment with low-dose BP. The high-dose BP (HBP) group consisted of 12 bone metastasis patients undergoing high-dose BP treatment. The Control group was 47 subjects with oral disease who had never been treated with an anti-resorptive agent. Our analyses demonstrated that with long-term BP administration, the bone metabolism of the iliac crest and intertrochanteric femur was suppressed but that of the mandible was enhanced. There was no significant difference in bone metabolism with either the low-dose BP or high-dose BP treatment. The effects of the long-term administration of BP were site-specific. Keywords: Mandibular metabolism, Long-term, BP, Anti-resorptive agent, Bone scintigraphy, Jaw |
| first_indexed | 2024-12-23T13:34:38Z |
| format | Article |
| id | doaj.art-1f872d3ae23a41fca540d32fdb956798 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-23T13:34:38Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-1f872d3ae23a41fca540d32fdb9567982022-12-21T17:45:03ZengElsevierJapanese Dental Science Review1882-76162019-11-015515157Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication)Yumiko Ohbayashi0Fumi Nakai1Akinori Iwasaki2Takaaki Ogawa3Yuka Yamamoto4Yoshihiro Nishiyama5Minoru Miyake6Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan; Corresponding author. Present/permanent address: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, JapanDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, JapanDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, JapanDepartment of Radiology, Faculty of Medicine, Kagawa University, Kagawa, JapanDepartment of Radiology, Faculty of Medicine, Kagawa University, Kagawa, JapanDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, JapanSummary: It is not yet known why anti-resorptive agent-related osteonecrosis specifically affects the jaw. Here we assessed changes in the bone metabolism of the mandible in response to long-term bisphosphonate (BP) therapy, and we compared the bone metabolism changes of the mandible with those of other bone sites using a quantitative analysis by bone scintigraphy. The region of interest was selected by identifying without an abnormal accumulation of the mandible, humerus, second and fourth lumbar vertebrae, iliac crest, intertrochanteric femur and diaphysis. Bone scintigraphy images were quantified using a value we termed the ‘bone uptake value (BUV)’. In the low-dose bisphosphonate (LBP) group (n = 21), the patients were undergoing osteoporosis treatment with low-dose BP. The high-dose BP (HBP) group consisted of 12 bone metastasis patients undergoing high-dose BP treatment. The Control group was 47 subjects with oral disease who had never been treated with an anti-resorptive agent. Our analyses demonstrated that with long-term BP administration, the bone metabolism of the iliac crest and intertrochanteric femur was suppressed but that of the mandible was enhanced. There was no significant difference in bone metabolism with either the low-dose BP or high-dose BP treatment. The effects of the long-term administration of BP were site-specific. Keywords: Mandibular metabolism, Long-term, BP, Anti-resorptive agent, Bone scintigraphy, Jawhttp://www.sciencedirect.com/science/article/pii/S1882761618301029 |
| spellingShingle | Yumiko Ohbayashi Fumi Nakai Akinori Iwasaki Takaaki Ogawa Yuka Yamamoto Yoshihiro Nishiyama Minoru Miyake Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) Japanese Dental Science Review |
| title | Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) |
| title_full | Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) |
| title_fullStr | Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) |
| title_full_unstemmed | Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) |
| title_short | Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication) |
| title_sort | symposium imaging modalities for drug related osteonecrosis of the jaw 6 assessment of mandibular metabolism due to long term administration of an anti resorptive agent by bone scintigraphy secondary publication |
| url | http://www.sciencedirect.com/science/article/pii/S1882761618301029 |
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