Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study
BackgroundIn children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions versus promotion of physical activity. Nevertheless, in children with LQTS, cardiorespiratory fitness, muscle fitness, and physica...
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| Format: | Article |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1081106/full |
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| author | Luc Souilla Luc Souilla Martina Avesani Aymeric Boisson Anne Requirand Anne Requirand Stefan Matecki Stefan Matecki Marie Vincenti Marie Vincenti Oscar Werner Oscar Werner Gregoire De La Villeon Gregoire De La Villeon Victor Pommier Victor Pommier Jean-Luc Pasquie Jean-Luc Pasquie Sophie Guillaumont Sophie Guillaumont Pascal Amedro Pascal Amedro |
| author_facet | Luc Souilla Luc Souilla Martina Avesani Aymeric Boisson Anne Requirand Anne Requirand Stefan Matecki Stefan Matecki Marie Vincenti Marie Vincenti Oscar Werner Oscar Werner Gregoire De La Villeon Gregoire De La Villeon Victor Pommier Victor Pommier Jean-Luc Pasquie Jean-Luc Pasquie Sophie Guillaumont Sophie Guillaumont Pascal Amedro Pascal Amedro |
| author_sort | Luc Souilla |
| collection | DOAJ |
| description | BackgroundIn children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions versus promotion of physical activity. Nevertheless, in children with LQTS, cardiorespiratory fitness, muscle fitness, and physical activity, have been scarcely explored.Materials and methodsIn this prospective, controlled, cross-sectional study, 20 children with LQTS (12.7 ± 3.7 years old) and 20 healthy controls (11.9 ± 2.4 years old) were enrolled. All participants underwent a cardiopulmonary exercise test, a muscular architecture ultrasound assessment, (cross-sectional area on right rectus femoris and pennation angle), a handgrip muscular strength evaluation, and a standing long broad jump test. The level of physical activity was determined using with a waist-worn tri-axial accelerometer (Actigraph GT3X).ResultsPeak oxygen uptake (VO2peak) and ventilatory anaerobic threshold (VAT) were lower in children with LQTS than in healthy controls (33.9 ± 6.2 mL/Kg/min vs. 40.1 ± 6.6 mL/Kg/min, P = 0.010; 23.8 ± 5.1 mL/Kg/min vs. 28.8 ± 5.5 mL/Kg/min, P = 0.007, respectively). Children with LQTS had lower standing long broad jump distance (119.5 ± 33.2 cm vs. 147.3 ± 36.1 cm, P = 0.02) and pennation angle (12.2 ± 2.4° vs. 14.3 ± 2.8°, P = 0.02). No differences in terms of moderate-to-vigorous physical activity were observed (36.9 ± 12.9 min/day vs. 41.5 ± 18.7 min/day, P = 0.66), but nearly all children were below the WHO guidelines.ConclusionDespite similar physical activity level, cardiorespiratory fitness and muscle fitness in children with LQTS were lower than in healthy controls. The origin of this limitation seemed to be multifactorial, involving beta-blocker induced chronotropic limitation, physical and muscle deconditioning. Cardiovascular rehabilitation could be of interest in children with LQTS with significant physical limitation. |
| first_indexed | 2024-04-10T23:44:25Z |
| format | Article |
| id | doaj.art-1f87c36703ad46b5b0bca90c43f4bcd6 |
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| language | English |
| last_indexed | 2024-04-10T23:44:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-1f87c36703ad46b5b0bca90c43f4bcd62023-01-11T05:17:22ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10811061081106Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled studyLuc Souilla0Luc Souilla1Martina Avesani2Aymeric Boisson3Anne Requirand4Anne Requirand5Stefan Matecki6Stefan Matecki7Marie Vincenti8Marie Vincenti9Oscar Werner10Oscar Werner11Gregoire De La Villeon12Gregoire De La Villeon13Victor Pommier14Victor Pommier15Jean-Luc Pasquie16Jean-Luc Pasquie17Sophie Guillaumont18Sophie Guillaumont19Pascal Amedro20Pascal Amedro21Department of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePhyMedExp, Univ Montpellier, INSERM, French National Centre for Scientific Research (CNRS), Montpellier, FranceDepartment of Paediatric and Adult Congenital Cardiology, M3C National Reference Centre, Bordeaux University Hospital, Pessac, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FranceDepartment of Physiology, University Hospital of Montpellier, Montpellier, FrancePhyMedExp, Univ Montpellier, INSERM, French National Centre for Scientific Research (CNRS), Montpellier, FranceDepartment of Physiology, University Hospital of Montpellier, Montpellier, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePhyMedExp, Univ Montpellier, INSERM, French National Centre for Scientific Research (CNRS), Montpellier, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePaediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, Palavas-Les-Flots, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePaediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, Palavas-Les-Flots, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePaediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, Palavas-Les-Flots, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePhyMedExp, Univ Montpellier, INSERM, French National Centre for Scientific Research (CNRS), Montpellier, FranceDepartment of Paediatric and Congenital Cardiology, M3C Regional Reference Centre, University Hospital, Montpellier, FrancePaediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, Palavas-Les-Flots, FranceDepartment of Paediatric and Adult Congenital Cardiology, M3C National Reference Centre, Bordeaux University Hospital, Pessac, FranceInserm, U1045, Institut Hospitalo-Universitaire (IHU) Liryc, Bordeaux Cardio-Thoracic Research Centre, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, FranceBackgroundIn children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions versus promotion of physical activity. Nevertheless, in children with LQTS, cardiorespiratory fitness, muscle fitness, and physical activity, have been scarcely explored.Materials and methodsIn this prospective, controlled, cross-sectional study, 20 children with LQTS (12.7 ± 3.7 years old) and 20 healthy controls (11.9 ± 2.4 years old) were enrolled. All participants underwent a cardiopulmonary exercise test, a muscular architecture ultrasound assessment, (cross-sectional area on right rectus femoris and pennation angle), a handgrip muscular strength evaluation, and a standing long broad jump test. The level of physical activity was determined using with a waist-worn tri-axial accelerometer (Actigraph GT3X).ResultsPeak oxygen uptake (VO2peak) and ventilatory anaerobic threshold (VAT) were lower in children with LQTS than in healthy controls (33.9 ± 6.2 mL/Kg/min vs. 40.1 ± 6.6 mL/Kg/min, P = 0.010; 23.8 ± 5.1 mL/Kg/min vs. 28.8 ± 5.5 mL/Kg/min, P = 0.007, respectively). Children with LQTS had lower standing long broad jump distance (119.5 ± 33.2 cm vs. 147.3 ± 36.1 cm, P = 0.02) and pennation angle (12.2 ± 2.4° vs. 14.3 ± 2.8°, P = 0.02). No differences in terms of moderate-to-vigorous physical activity were observed (36.9 ± 12.9 min/day vs. 41.5 ± 18.7 min/day, P = 0.66), but nearly all children were below the WHO guidelines.ConclusionDespite similar physical activity level, cardiorespiratory fitness and muscle fitness in children with LQTS were lower than in healthy controls. The origin of this limitation seemed to be multifactorial, involving beta-blocker induced chronotropic limitation, physical and muscle deconditioning. Cardiovascular rehabilitation could be of interest in children with LQTS with significant physical limitation.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1081106/fullpediatricslong QT syndromeinherited cardiac arrythmiacardiorespiratory fitnessmuscle fitnessphysical activity |
| spellingShingle | Luc Souilla Luc Souilla Martina Avesani Aymeric Boisson Anne Requirand Anne Requirand Stefan Matecki Stefan Matecki Marie Vincenti Marie Vincenti Oscar Werner Oscar Werner Gregoire De La Villeon Gregoire De La Villeon Victor Pommier Victor Pommier Jean-Luc Pasquie Jean-Luc Pasquie Sophie Guillaumont Sophie Guillaumont Pascal Amedro Pascal Amedro Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study Frontiers in Cardiovascular Medicine pediatrics long QT syndrome inherited cardiac arrythmia cardiorespiratory fitness muscle fitness physical activity |
| title | Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study |
| title_full | Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study |
| title_fullStr | Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study |
| title_full_unstemmed | Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study |
| title_short | Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study |
| title_sort | cardiorespiratory fitness muscle fitness and physical activity in children with long qt syndrome a prospective controlled study |
| topic | pediatrics long QT syndrome inherited cardiac arrythmia cardiorespiratory fitness muscle fitness physical activity |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1081106/full |
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