Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological func...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2023/4190849 |
| _version_ | 1811165458533974016 |
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| author | Kai Guo Lingling Fang Mingjian Li Aizheng Li Na Liu |
| author_facet | Kai Guo Lingling Fang Mingjian Li Aizheng Li Na Liu |
| author_sort | Kai Guo |
| collection | DOAJ |
| description | Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505. Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505. |
| first_indexed | 2024-04-10T15:37:25Z |
| format | Article |
| id | doaj.art-1f88c4c810ca4f34949e99fd327a53af |
| institution | Directory Open Access Journal |
| issn | 1875-8584 |
| language | English |
| last_indexed | 2024-04-10T15:37:25Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj.art-1f88c4c810ca4f34949e99fd327a53af2023-02-13T01:08:13ZengHindawi LimitedBehavioural Neurology1875-85842023-01-01202310.1155/2023/4190849Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma ProgressionKai Guo0Lingling Fang1Mingjian Li2Aizheng Li3Na Liu4Department of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of NeurologyGlioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505. Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505.http://dx.doi.org/10.1155/2023/4190849 |
| spellingShingle | Kai Guo Lingling Fang Mingjian Li Aizheng Li Na Liu Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression Behavioural Neurology |
| title | Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression |
| title_full | Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression |
| title_fullStr | Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression |
| title_full_unstemmed | Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression |
| title_short | Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression |
| title_sort | long non coding rna ktn1 as1 targets mir 505 to promote glioblastoma progression |
| url | http://dx.doi.org/10.1155/2023/4190849 |
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