Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies
Background: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-12-01
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| Series: | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S209588111630004X |
| _version_ | 1818234037471281152 |
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| author | Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid |
| author_facet | Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid |
| author_sort | Judd H. Fastenberg |
| collection | DOAJ |
| description | Background: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CRS. Objective: This review seeks to explore the evidence implicating biofilms in CRS, discuss potential anti-biofilm therapeutic strategies, and suggest future directions for research. Results: The existing evidence strongly supports the role of biofilms in the pathogenesis of CRS. Several anti-biofilm therapies have been investigated for use in CRS and these are at variable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quorum sensing. Several of the most promising anti-biofilm therapeutic strategies are reviewed. Conclusions: A better understanding of biofilm function and their contribution to the CRS disease process will be pivotal to the development of novel treatments that may augment and, potentially, redefine the CRS treatment paradigm. There is tremendous potential for future research. Keywords: Sinusitis, Biofilms, Anti-bacterial agents, Quorum sensing, Surface-active agents, Active immune response, Innate immune response |
| first_indexed | 2024-12-12T11:31:42Z |
| format | Article |
| id | doaj.art-1f88e4a5eeaf473ca3e83bed2e192382 |
| institution | Directory Open Access Journal |
| issn | 2095-8811 |
| language | English |
| last_indexed | 2024-12-12T11:31:42Z |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| spelling | doaj.art-1f88e4a5eeaf473ca3e83bed2e1923822022-12-22T00:25:46ZengWileyWorld Journal of Otorhinolaryngology-Head and Neck Surgery2095-88112016-12-0124219229Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategiesJudd H. Fastenberg0Wayne D. Hsueh1Ali Mustafa2Nadeem A. Akbar3Waleed M. Abuzeid4Corresponding author.; Department of Otorhinolaryngology â Head & Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Bronx, NY, 10467, USADepartment of Otorhinolaryngology â Head & Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Bronx, NY, 10467, USADepartment of Otorhinolaryngology â Head & Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Bronx, NY, 10467, USADepartment of Otorhinolaryngology â Head & Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Bronx, NY, 10467, USACorresponding author. Tel.: +1 718 920 4267; fax: +1 718 405 9014.; Department of Otorhinolaryngology â Head & Neck Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Bronx, NY, 10467, USABackground: There is increasing evidence that biofilms are critical to the pathophysiology of chronic infections including chronic rhinosinusitis (CRS). Until relatively recently, our understanding of biofilms was limited. Recent advances in methods for biofilm identification and molecular biology have offered new insights into the role of biofilms in CRS. With these insights, investigators have begun to investigate novel therapeutic strategies that may disrupt or eradicate biofilms in CRS. Objective: This review seeks to explore the evidence implicating biofilms in CRS, discuss potential anti-biofilm therapeutic strategies, and suggest future directions for research. Results: The existing evidence strongly supports the role of biofilms in the pathogenesis of CRS. Several anti-biofilm therapies have been investigated for use in CRS and these are at variable stages of development. Generally, these strategies: 1) neutralize biofilm microbes; 2) disperse existing biofilms; or 3) disrupt quorum sensing. Several of the most promising anti-biofilm therapeutic strategies are reviewed. Conclusions: A better understanding of biofilm function and their contribution to the CRS disease process will be pivotal to the development of novel treatments that may augment and, potentially, redefine the CRS treatment paradigm. There is tremendous potential for future research. Keywords: Sinusitis, Biofilms, Anti-bacterial agents, Quorum sensing, Surface-active agents, Active immune response, Innate immune responsehttp://www.sciencedirect.com/science/article/pii/S209588111630004X |
| spellingShingle | Judd H. Fastenberg Wayne D. Hsueh Ali Mustafa Nadeem A. Akbar Waleed M. Abuzeid Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies World Journal of Otorhinolaryngology-Head and Neck Surgery |
| title | Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies |
| title_full | Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies |
| title_fullStr | Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies |
| title_full_unstemmed | Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies |
| title_short | Biofilms in chronic rhinosinusitis: Pathophysiology and therapeutic strategies |
| title_sort | biofilms in chronic rhinosinusitis pathophysiology and therapeutic strategies |
| url | http://www.sciencedirect.com/science/article/pii/S209588111630004X |
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