Diabetes-induced male infertility: potential mechanisms and treatment options
Abstract Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-023-00771-x |
| _version_ | 1797349832748171264 |
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| author | Runchun Huang Jiawang Chen Buyu Guo Chenjun Jiang Weiming Sun |
| author_facet | Runchun Huang Jiawang Chen Buyu Guo Chenjun Jiang Weiming Sun |
| author_sort | Runchun Huang |
| collection | DOAJ |
| description | Abstract Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive problems, especially infertility, shows a very similar trend to the incidence of diabetes within the same age range. In addition, a large number of previous in vivo and in vitro experiments have also suggested that the complex pathophysiological changes caused by diabetes may induce male infertility in multiple aspects, including hypothalamic-pituitary–gonadal axis dysfunction, spermatogenesis and maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on the above related mechanisms, a large number of studies have focused on the potential therapeutic association between diabetes progression and infertility in patients with diabetes and infertility, providing important clues for the treatment of this population. In this paper, we summarized the research results of the effects of diabetes on male reproductive function in recent 5 years, elaborated the potential pathophysiological mechanisms of male infertility induced by diabetes, and reviewed and prospected the therapeutic measures. |
| first_indexed | 2024-03-08T12:36:10Z |
| format | Article |
| id | doaj.art-1f8c594eddbe43768a9ac88eaeac0ed7 |
| institution | Directory Open Access Journal |
| issn | 1528-3658 |
| language | English |
| last_indexed | 2024-03-08T12:36:10Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-1f8c594eddbe43768a9ac88eaeac0ed72024-01-21T12:25:06ZengBMCMolecular Medicine1528-36582024-01-0130111510.1186/s10020-023-00771-xDiabetes-induced male infertility: potential mechanisms and treatment optionsRunchun Huang0Jiawang Chen1Buyu Guo2Chenjun Jiang3Weiming Sun4The First Clinical Medical College, Lanzhou UniversityThe First Clinical Medical College, Lanzhou UniversityThe First Clinical Medical College, Lanzhou UniversityThe First Clinical Medical College, Lanzhou UniversityThe First Clinical Medical College, Lanzhou UniversityAbstract Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive problems, especially infertility, shows a very similar trend to the incidence of diabetes within the same age range. In addition, a large number of previous in vivo and in vitro experiments have also suggested that the complex pathophysiological changes caused by diabetes may induce male infertility in multiple aspects, including hypothalamic-pituitary–gonadal axis dysfunction, spermatogenesis and maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on the above related mechanisms, a large number of studies have focused on the potential therapeutic association between diabetes progression and infertility in patients with diabetes and infertility, providing important clues for the treatment of this population. In this paper, we summarized the research results of the effects of diabetes on male reproductive function in recent 5 years, elaborated the potential pathophysiological mechanisms of male infertility induced by diabetes, and reviewed and prospected the therapeutic measures.https://doi.org/10.1186/s10020-023-00771-xDiabetesMale infertilityHyperglycemiaOxidative stressChronic inflammationEndocrine disorders |
| spellingShingle | Runchun Huang Jiawang Chen Buyu Guo Chenjun Jiang Weiming Sun Diabetes-induced male infertility: potential mechanisms and treatment options Molecular Medicine Diabetes Male infertility Hyperglycemia Oxidative stress Chronic inflammation Endocrine disorders |
| title | Diabetes-induced male infertility: potential mechanisms and treatment options |
| title_full | Diabetes-induced male infertility: potential mechanisms and treatment options |
| title_fullStr | Diabetes-induced male infertility: potential mechanisms and treatment options |
| title_full_unstemmed | Diabetes-induced male infertility: potential mechanisms and treatment options |
| title_short | Diabetes-induced male infertility: potential mechanisms and treatment options |
| title_sort | diabetes induced male infertility potential mechanisms and treatment options |
| topic | Diabetes Male infertility Hyperglycemia Oxidative stress Chronic inflammation Endocrine disorders |
| url | https://doi.org/10.1186/s10020-023-00771-x |
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