Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation
IntroductionSubthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) in Parkinson’s disease (PD). The beta band is further dissected into low-and high-frequency components with somewhat different functions, alth...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1163811/full |
| _version_ | 1797824086196355072 |
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| author | Giulia Giannini Giulia Giannini Luca Baldelli Gaetano Leogrande Ilaria Cani Paolo Mantovani Giovanna Lopane Pietro Cortelli Pietro Cortelli Giovanna Calandra-Buonaura Giovanna Calandra-Buonaura Alfredo Conti Alfredo Conti |
| author_facet | Giulia Giannini Giulia Giannini Luca Baldelli Gaetano Leogrande Ilaria Cani Paolo Mantovani Giovanna Lopane Pietro Cortelli Pietro Cortelli Giovanna Calandra-Buonaura Giovanna Calandra-Buonaura Alfredo Conti Alfredo Conti |
| author_sort | Giulia Giannini |
| collection | DOAJ |
| description | IntroductionSubthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) in Parkinson’s disease (PD). The beta band is further dissected into low-and high-frequency components with somewhat different functions, although their concomitance and association in the single patient is far to be defined. We present a 56-year-old male PD patient undergoing DBS showing a double-beta peak activity on both sides. The aim of the study was to investigate how low-and high-beta peaks were influenced by plasma levodopa (L-dopa) levels, stimulation, and motor performances.MethodsA systematic evaluation of raw LFPs, plasma L-dopa levels, and motor tasks was performed in the following four conditions: OFF medications/ON stimulation, OFF medications/OFF stimulation, ON medications/OFF stimulation, and ON medications/ON stimulation.ResultsThe analysis of the LFP spectra suggests the following results: (1) the high-beta peak was suppressed by stimulation, while the low-beta peak showed a partial and not consistent response to stimulation; (2) the high-beta peak is also influenced by plasma L-dopa concentration, showing a progressive amplitude increment concordant with plasma L-dopa levels, while the low-beta peak shows a different behavir; and (3) motor performances seem to impact beta peaks behavior.ConclusionThis single exploratory case study illustrates a complex behavior of low-and high-beta peaks in a PD patient, in response to stimulation, L-dopa plasma levels, and motor performances. Our results suggest the importance to investigate patient-specific individual LFP patterns in view of upcoming closed-loop stimulation. |
| first_indexed | 2024-03-13T10:33:46Z |
| format | Article |
| id | doaj.art-1f8d3b9726d749849800f508eaa152b6 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T10:33:46Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1f8d3b9726d749849800f508eaa152b62023-05-18T07:08:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-05-011410.3389/fneur.2023.11638111163811Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulationGiulia Giannini0Giulia Giannini1Luca Baldelli2Gaetano Leogrande3Ilaria Cani4Paolo Mantovani5Giovanna Lopane6Pietro Cortelli7Pietro Cortelli8Giovanna Calandra-Buonaura9Giovanna Calandra-Buonaura10Alfredo Conti11Alfredo Conti12UOC Clinica Neurologica Rete Metropolitana NEUROMET, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyMedtronic EMEA Corporate Technology and Innovation, Maastricht, NetherlandsDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyUnit of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyUnit of Rehabilitation Medicine, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyUOC Clinica Neurologica Rete Metropolitana NEUROMET, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyUOC Clinica Neurologica Rete Metropolitana NEUROMET, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum - University of Bologna, Bologna, ItalyUnit of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyIntroductionSubthalamic (STN) local field potentials (LFPs) in the beta band are considered potential biomarkers for closed-loop deep brain stimulation (DBS) in Parkinson’s disease (PD). The beta band is further dissected into low-and high-frequency components with somewhat different functions, although their concomitance and association in the single patient is far to be defined. We present a 56-year-old male PD patient undergoing DBS showing a double-beta peak activity on both sides. The aim of the study was to investigate how low-and high-beta peaks were influenced by plasma levodopa (L-dopa) levels, stimulation, and motor performances.MethodsA systematic evaluation of raw LFPs, plasma L-dopa levels, and motor tasks was performed in the following four conditions: OFF medications/ON stimulation, OFF medications/OFF stimulation, ON medications/OFF stimulation, and ON medications/ON stimulation.ResultsThe analysis of the LFP spectra suggests the following results: (1) the high-beta peak was suppressed by stimulation, while the low-beta peak showed a partial and not consistent response to stimulation; (2) the high-beta peak is also influenced by plasma L-dopa concentration, showing a progressive amplitude increment concordant with plasma L-dopa levels, while the low-beta peak shows a different behavir; and (3) motor performances seem to impact beta peaks behavior.ConclusionThis single exploratory case study illustrates a complex behavior of low-and high-beta peaks in a PD patient, in response to stimulation, L-dopa plasma levels, and motor performances. Our results suggest the importance to investigate patient-specific individual LFP patterns in view of upcoming closed-loop stimulation.https://www.frontiersin.org/articles/10.3389/fneur.2023.1163811/fullParkinson’s diseasedeep brain stimulationlocal field potentialsbeta band frequencycase report |
| spellingShingle | Giulia Giannini Giulia Giannini Luca Baldelli Gaetano Leogrande Ilaria Cani Paolo Mantovani Giovanna Lopane Pietro Cortelli Pietro Cortelli Giovanna Calandra-Buonaura Giovanna Calandra-Buonaura Alfredo Conti Alfredo Conti Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation Frontiers in Neurology Parkinson’s disease deep brain stimulation local field potentials beta band frequency case report |
| title | Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation |
| title_full | Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation |
| title_fullStr | Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation |
| title_full_unstemmed | Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation |
| title_short | Case report: Bilateral double beta peak activity is influenced by stimulation, levodopa concentrations, and motor tasks, in a Parkinson’s disease patient on chronic deep brain stimulation |
| title_sort | case report bilateral double beta peak activity is influenced by stimulation levodopa concentrations and motor tasks in a parkinson s disease patient on chronic deep brain stimulation |
| topic | Parkinson’s disease deep brain stimulation local field potentials beta band frequency case report |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1163811/full |
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