The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges
Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770523001018 |
| _version_ | 1797394800860725248 |
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| author | Ya-Nan Wei Chun-Yan Yan Meng-Lu Zhao Xi-He Zhao |
| author_facet | Ya-Nan Wei Chun-Yan Yan Meng-Lu Zhao Xi-He Zhao |
| author_sort | Ya-Nan Wei |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment. |
| first_indexed | 2024-03-09T00:24:59Z |
| format | Article |
| id | doaj.art-1f8dc8db2b564f5b99d1011e26376845 |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-03-09T00:24:59Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-1f8dc8db2b564f5b99d1011e263768452023-12-12T04:35:19ZengElsevierMolecular Therapy: Oncolytics2372-77052023-12-0131100752The role and application of vesicles in triple-negative breast cancer: Opportunities and challengesYa-Nan Wei0Chun-Yan Yan1Meng-Lu Zhao2Xi-He Zhao3Department of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People’s Republic of ChinaDepartment of Clinical Oncology, Sheng jing Hospital of China Medical University, Shenyang 110022, People’s Republic of China; Corresponding author: Xi-He Zhao, MD, PhD, Department of Clinical Oncology, Sheng jing Hospital of China Medical University Shenyang, Shenyan 110022, People’s Republic of China.Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.http://www.sciencedirect.com/science/article/pii/S2372770523001018Triple-negative breast cancervesicletumor microenvironment/host-tumor interactionsliquid biopsydrug resistance/biochemistry of membrane metabolism and transportion |
| spellingShingle | Ya-Nan Wei Chun-Yan Yan Meng-Lu Zhao Xi-He Zhao The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges Molecular Therapy: Oncolytics Triple-negative breast cancer vesicle tumor microenvironment/host-tumor interactions liquid biopsy drug resistance/biochemistry of membrane metabolism and transportion |
| title | The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges |
| title_full | The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges |
| title_fullStr | The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges |
| title_full_unstemmed | The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges |
| title_short | The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges |
| title_sort | role and application of vesicles in triple negative breast cancer opportunities and challenges |
| topic | Triple-negative breast cancer vesicle tumor microenvironment/host-tumor interactions liquid biopsy drug resistance/biochemistry of membrane metabolism and transportion |
| url | http://www.sciencedirect.com/science/article/pii/S2372770523001018 |
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