The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells

The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells

miR-27a plays a driver role in rewiring tumor cell metabolism. We searched for new miR-27a targets that could affect mitochondria and identified FOXJ3, an apical factor of mitochondrial biogenesis. We analyzed FOXJ3 levels in an in vitro cell model system that was genetically modified for miR-27a ex...

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Bibliographic Details
Main Authors: Giovannina Barisciano, Manuela Leo, Livio Muccillo, Erica Pranzini, Matteo Parri, Vittorio Colantuoni, Maria Letizia Taddei, Lina Sabatino
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
colorectal cancer
FOXJ3
miRNA
mitochondria
tumor metabolism
Online Access:https://www.mdpi.com/2072-6694/13/19/4994

Internet

https://www.mdpi.com/2072-6694/13/19/4994

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