Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer

Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and incidence rates are continuing to rise globally. Patients often present with locally advanced disease and a staggering 50% chance of relapse following treatment. Aberrant activation of adaptive response signali...

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Bibliographic Details
Main Authors: Miranda B. Carper, Saumya Goel, Anna M. Zhang, Jeffrey S. Damrauer, Stephanie Cohen, Matthew P. Zimmerman, Gabrielle M. Gentile, Kshitij Parag-Sharma, Ryan M. Murphy, Kotaro Sato, Kwangok P. Nickel, Randall J. Kimple, Wendell G. Yarbrough, Antonio L. Amelio
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Head and neck cancer
CREB
cAMP Regulated transcription coactivators
HPV(+) oropharyngeal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000264

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