Characteristics of acute ischemic stroke in patients with Nephrotic syndrome
The incidence of ischemic stroke (IS) is higher in nephrotic syndrome (NS) patients compared to general population. However, there is limited information on the specific characteristics to stroke patients with NS. In this study, we aimed to examine the clinical manifestations of acute IS in a large...
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| 格式: | Article |
| 語言: | English |
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Taylor & Francis Group
2023-12-01
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| 叢編: | Renal Failure |
| 主題: | |
| 在線閱讀: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2284214 |
| _version_ | 1831871152400629760 |
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| author | Wen-Yi Huang Chun-Wei Chang Kuan-Hsing Chen Chien-Hung Chang Hsiu-Chuan Wu Kuo-Hsuan Chang |
| author_facet | Wen-Yi Huang Chun-Wei Chang Kuan-Hsing Chen Chien-Hung Chang Hsiu-Chuan Wu Kuo-Hsuan Chang |
| author_sort | Wen-Yi Huang |
| collection | DOAJ |
| description | The incidence of ischemic stroke (IS) is higher in nephrotic syndrome (NS) patients compared to general population. However, there is limited information on the specific characteristics to stroke patients with NS. In this study, we aimed to examine the clinical manifestations of acute IS in a large group of NS patients, comparing to those without NS. We conducted a retrospective cohort study to compare the clinical presentations of acute IS in patients with and without NS. This study was a multi-institutional study and used data from Chang Gung Research Database of Taiwan from 1 January 2001, to 31 December 2017. A total of 233 IS patients with NS and 1358 IS patients without NS were enrolled. The median age of participants was 68 (range: 59–79) years. The risk of dependent functional status (modified Rankin Scale score≧3) after IS was higher in NS patients compared to those without NS (Odd ratio (OR) 4.02, 95% confidence interval (CI) 2.39 to 6.76, p < 0.001), particularly in stroke subtypes as small-artery occlusion (OR 8.02, 95% CI 3.94 to 16.32, p < 0.001), and stroke of undetermined etiology (OR 2.47, CI 1.06 to 5.76, p = 037). The risks of mortality or stroke recurrence within 30 days were similar between the two groups for all stroke subtypes. In conclusion, NS was associated with a higher risk of functional dependence following IS. Intensive treatment and rehabilitation should be considered for IS patients with NS. |
| first_indexed | 2024-03-09T01:10:22Z |
| format | Article |
| id | doaj.art-1f9025b78f8d4b9b95514cdf3b9d68e5 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2025-03-21T19:37:15Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-1f9025b78f8d4b9b95514cdf3b9d68e52024-06-03T10:02:15ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2284214Characteristics of acute ischemic stroke in patients with Nephrotic syndromeWen-Yi Huang0Chun-Wei Chang1Kuan-Hsing Chen2Chien-Hung Chang3Hsiu-Chuan Wu4Kuo-Hsuan Chang5Department of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Keelung branch, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Linkou branch, TaiwanKidney Research Center, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Linkou branch, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Linkou branch, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Linkou branch, TaiwanThe incidence of ischemic stroke (IS) is higher in nephrotic syndrome (NS) patients compared to general population. However, there is limited information on the specific characteristics to stroke patients with NS. In this study, we aimed to examine the clinical manifestations of acute IS in a large group of NS patients, comparing to those without NS. We conducted a retrospective cohort study to compare the clinical presentations of acute IS in patients with and without NS. This study was a multi-institutional study and used data from Chang Gung Research Database of Taiwan from 1 January 2001, to 31 December 2017. A total of 233 IS patients with NS and 1358 IS patients without NS were enrolled. The median age of participants was 68 (range: 59–79) years. The risk of dependent functional status (modified Rankin Scale score≧3) after IS was higher in NS patients compared to those without NS (Odd ratio (OR) 4.02, 95% confidence interval (CI) 2.39 to 6.76, p < 0.001), particularly in stroke subtypes as small-artery occlusion (OR 8.02, 95% CI 3.94 to 16.32, p < 0.001), and stroke of undetermined etiology (OR 2.47, CI 1.06 to 5.76, p = 037). The risks of mortality or stroke recurrence within 30 days were similar between the two groups for all stroke subtypes. In conclusion, NS was associated with a higher risk of functional dependence following IS. Intensive treatment and rehabilitation should be considered for IS patients with NS.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2284214Nephrotic syndromestrokeischemic strokecerebral infarctionchronic kidney disease |
| spellingShingle | Wen-Yi Huang Chun-Wei Chang Kuan-Hsing Chen Chien-Hung Chang Hsiu-Chuan Wu Kuo-Hsuan Chang Characteristics of acute ischemic stroke in patients with Nephrotic syndrome Renal Failure Nephrotic syndrome stroke ischemic stroke cerebral infarction chronic kidney disease |
| title | Characteristics of acute ischemic stroke in patients with Nephrotic syndrome |
| title_full | Characteristics of acute ischemic stroke in patients with Nephrotic syndrome |
| title_fullStr | Characteristics of acute ischemic stroke in patients with Nephrotic syndrome |
| title_full_unstemmed | Characteristics of acute ischemic stroke in patients with Nephrotic syndrome |
| title_short | Characteristics of acute ischemic stroke in patients with Nephrotic syndrome |
| title_sort | characteristics of acute ischemic stroke in patients with nephrotic syndrome |
| topic | Nephrotic syndrome stroke ischemic stroke cerebral infarction chronic kidney disease |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2284214 |
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