Lymphogranuloma venereum: diagnostic and treatment challenges
Romana Ceovic,1 Sandra Jerkovic Gulin21Department of Dermatology and Venereology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia; 2Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, CroatiaAbstract: Lymphogranuloma venereum is a sexually transmit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-03-01
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| Series: | Infection and Drug Resistance |
| Online Access: | http://www.dovepress.com/lymphogranuloma-venereum-diagnostic-and-treatment-challenges-peer-reviewed-article-IDR |
| _version_ | 1819029101190578176 |
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| author | Ceovic R Jerkovic Gulin S |
| author_facet | Ceovic R Jerkovic Gulin S |
| author_sort | Ceovic R |
| collection | DOAJ |
| description | Romana Ceovic,1 Sandra Jerkovic Gulin21Department of Dermatology and Venereology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia; 2Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, CroatiaAbstract: Lymphogranuloma venereum is a sexually transmitted disease caused by L1, L2, and L3 serovars of Chlamydia trachomatis. In the last 10 years outbreaks have appeared in North America, Europe, and Australia in the form of proctitis among men who have sex with men. Three stages of disease have been described. The disease in primary stage may go undetected when only a painless papule, pustule, or ulceration appears. The diagnosis is difficult to establish on clinical grounds alone and frequently relies upon either serologic testing, culture, or more recently, nucleic acid amplification testing of direct specimens. A proper treatment regimen cures the infection and prevents further damage to tissues. Lymphogranuloma venereum causes potentially severe infections with possibly irreversible sequels if adequate treatment is not begun promptly. Early and accurate diagnosis is essential. Doxycycline is the drug of choice. Pregnant and lactating women should be treated with erythromycin or azithromycin. Patient must be followed up during the treatment, until disease signs and symptoms have resolved. Repeated testing for syphilis, hepatitis B and C, and HIV to detect early infection should be performed.Keywords: sexually transmitted disease, Chlamydia trachomatis, early and accurate diagnosis |
| first_indexed | 2024-12-21T06:08:54Z |
| format | Article |
| id | doaj.art-1f907aaac897442d96a8f1fd58c0b963 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-21T06:08:54Z |
| publishDate | 2015-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-1f907aaac897442d96a8f1fd58c0b9632022-12-21T19:13:34ZengDove Medical PressInfection and Drug Resistance1178-69732015-03-012015default394721047Lymphogranuloma venereum: diagnostic and treatment challengesCeovic RJerkovic Gulin SRomana Ceovic,1 Sandra Jerkovic Gulin21Department of Dermatology and Venereology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia; 2Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, CroatiaAbstract: Lymphogranuloma venereum is a sexually transmitted disease caused by L1, L2, and L3 serovars of Chlamydia trachomatis. In the last 10 years outbreaks have appeared in North America, Europe, and Australia in the form of proctitis among men who have sex with men. Three stages of disease have been described. The disease in primary stage may go undetected when only a painless papule, pustule, or ulceration appears. The diagnosis is difficult to establish on clinical grounds alone and frequently relies upon either serologic testing, culture, or more recently, nucleic acid amplification testing of direct specimens. A proper treatment regimen cures the infection and prevents further damage to tissues. Lymphogranuloma venereum causes potentially severe infections with possibly irreversible sequels if adequate treatment is not begun promptly. Early and accurate diagnosis is essential. Doxycycline is the drug of choice. Pregnant and lactating women should be treated with erythromycin or azithromycin. Patient must be followed up during the treatment, until disease signs and symptoms have resolved. Repeated testing for syphilis, hepatitis B and C, and HIV to detect early infection should be performed.Keywords: sexually transmitted disease, Chlamydia trachomatis, early and accurate diagnosishttp://www.dovepress.com/lymphogranuloma-venereum-diagnostic-and-treatment-challenges-peer-reviewed-article-IDR |
| spellingShingle | Ceovic R Jerkovic Gulin S Lymphogranuloma venereum: diagnostic and treatment challenges Infection and Drug Resistance |
| title | Lymphogranuloma venereum: diagnostic and treatment challenges |
| title_full | Lymphogranuloma venereum: diagnostic and treatment challenges |
| title_fullStr | Lymphogranuloma venereum: diagnostic and treatment challenges |
| title_full_unstemmed | Lymphogranuloma venereum: diagnostic and treatment challenges |
| title_short | Lymphogranuloma venereum: diagnostic and treatment challenges |
| title_sort | lymphogranuloma venereum diagnostic and treatment challenges |
| url | http://www.dovepress.com/lymphogranuloma-venereum-diagnostic-and-treatment-challenges-peer-reviewed-article-IDR |
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