Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice

Overexpressing p130/E2F4 in mesenchymal stem cells facilitates the repair of injured alveolar epithelial cells in LPS-induced ARDS mice

Abstract Background Low differentiation rates of mesenchymal stem cells (MSCs) limit their therapeutic effects on patients in clinical studies. Our previous study demonstrated that overexpressing p130 or E2F4 affected the multipotential differentiation of MSCs, and the underlying mechanism was attri...

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Bibliographic Details
Main Authors: Xiwen Zhang, Jianxiao Chen, Ming Xue, Yuying Tang, Jingyuan Xu, Ling Liu, Yingzi Huang, Yi Yang, Haibo Qiu, Fengmei Guo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Acute respiratory distress syndrome
p130
E2F4
Differentiation into type II alveolar epithelial cells
Online Access:http://link.springer.com/article/10.1186/s13287-019-1169-1

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