Three-dimensional visualization of cerebral blood vessels and neural changes in thick ischemic rat brain slices using tissue clearing
Abstract Blood vessels are three-dimensional (3D) in structure and precisely connected. Conventional histological methods are unsuitable for their analysis because of the destruction of functionally important topological 3D vascular structures. Tissue optical clearing techniques enable extensive vol...
Main Authors: | Eun-Joo Lee, Sung-Kuk Hong, Dong-Hwa Choi, Sang-Il Gum, Mee Yul Hwang, Dong Sun Kim, Ji Won Oh, Eun-Shil Lee |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-19575-w |
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