Three-dimensional visualization of cerebral blood vessels and neural changes in thick ischemic rat brain slices using tissue clearing

Abstract Blood vessels are three-dimensional (3D) in structure and precisely connected. Conventional histological methods are unsuitable for their analysis because of the destruction of functionally important topological 3D vascular structures. Tissue optical clearing techniques enable extensive vol...

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Bibliographic Details
Main Authors: Eun-Joo Lee, Sung-Kuk Hong, Dong-Hwa Choi, Sang-Il Gum, Mee Yul Hwang, Dong Sun Kim, Ji Won Oh, Eun-Shil Lee
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19575-w

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