Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial
Nitrate-rich food increases nitric oxide (NO) production and may have beneficial effects on vascular, metabolic, and brain function. This pilot study tested the effects of prolonged consumption of a range of doses of dietary nitrate (NO<sub>3</sub><sup>−</sup>), provided as b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1052 |
| _version_ | 1797474143920193536 |
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| author | Abrar M. Babateen Oliver M. Shannon Gerard M. O’Brien Edward Okello Ellen Smith Dilara Olgacer Christina Koehl William Fostier Emma Wightman David Kennedy John C. Mathers Mario Siervo |
| author_facet | Abrar M. Babateen Oliver M. Shannon Gerard M. O’Brien Edward Okello Ellen Smith Dilara Olgacer Christina Koehl William Fostier Emma Wightman David Kennedy John C. Mathers Mario Siervo |
| author_sort | Abrar M. Babateen |
| collection | DOAJ |
| description | Nitrate-rich food increases nitric oxide (NO) production and may have beneficial effects on vascular, metabolic, and brain function. This pilot study tested the effects of prolonged consumption of a range of doses of dietary nitrate (NO<sub>3</sub><sup>−</sup>), provided as beetroot juice, on cognitive function and cerebral blood flow (CBF) in overweight and obese older participants. The study had a 13-week single-blind, randomised, parallel design, and 62 overweight and obese older participants (aged 60 to 75 years) received the following interventions: (1) high NO<sub>3</sub><sup>−</sup> (2 × 70 mL beetroot juice/day) (2) medium NO<sub>3</sub><sup>−</sup> (70 mL beetroot juice/day), (3) low NO<sub>3</sub><sup>−</sup> (70 mL beetroot juice on alternate days), or (4) placebo (70 mL of NO<sub>3</sub><sup>−</sup>-depleted beetroot juice on alternate days). Cognitive functions were assessed using the Computerised Mental Performance Assessment System (COMPASS) assessment battery. CBF, monitored by concentration changes in oxygenated and deoxygenated haemoglobin, was assessed in the frontal cortex using near-infrared spectroscopy. The findings of this pilot study showed that cognitive function and CBF were not affected by supplementation with NO<sub>3</sub><sup>−</sup>-rich beetroot juice for 13 weeks, irrespective of the NO<sub>3</sub><sup>−</sup> dose administered. These findings require confirmation in larger studies using more sophisticated imaging methods (i.e., MRI) to determine whether prolonged dietary NO<sub>3</sub><sup>−</sup> supplementation influences brain function in older overweight people. |
| first_indexed | 2024-03-09T20:25:56Z |
| format | Article |
| id | doaj.art-1f9212bdb77e4c458bb791398e81d08d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:25:56Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1f9212bdb77e4c458bb791398e81d08d2023-11-23T23:33:47ZengMDPI AGNutrients2072-66432022-03-01145105210.3390/nu14051052Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical TrialAbrar M. Babateen0Oliver M. Shannon1Gerard M. O’Brien2Edward Okello3Ellen Smith4Dilara Olgacer5Christina Koehl6William Fostier7Emma Wightman8David Kennedy9John C. Mathers10Mario Siervo11Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKBrain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKBrain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UKBrain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UKNitrate-rich food increases nitric oxide (NO) production and may have beneficial effects on vascular, metabolic, and brain function. This pilot study tested the effects of prolonged consumption of a range of doses of dietary nitrate (NO<sub>3</sub><sup>−</sup>), provided as beetroot juice, on cognitive function and cerebral blood flow (CBF) in overweight and obese older participants. The study had a 13-week single-blind, randomised, parallel design, and 62 overweight and obese older participants (aged 60 to 75 years) received the following interventions: (1) high NO<sub>3</sub><sup>−</sup> (2 × 70 mL beetroot juice/day) (2) medium NO<sub>3</sub><sup>−</sup> (70 mL beetroot juice/day), (3) low NO<sub>3</sub><sup>−</sup> (70 mL beetroot juice on alternate days), or (4) placebo (70 mL of NO<sub>3</sub><sup>−</sup>-depleted beetroot juice on alternate days). Cognitive functions were assessed using the Computerised Mental Performance Assessment System (COMPASS) assessment battery. CBF, monitored by concentration changes in oxygenated and deoxygenated haemoglobin, was assessed in the frontal cortex using near-infrared spectroscopy. The findings of this pilot study showed that cognitive function and CBF were not affected by supplementation with NO<sub>3</sub><sup>−</sup>-rich beetroot juice for 13 weeks, irrespective of the NO<sub>3</sub><sup>−</sup> dose administered. These findings require confirmation in larger studies using more sophisticated imaging methods (i.e., MRI) to determine whether prolonged dietary NO<sub>3</sub><sup>−</sup> supplementation influences brain function in older overweight people.https://www.mdpi.com/2072-6643/14/5/1052inorganic nitratebeetroot juicecognitioncerebral blood flowolder adults |
| spellingShingle | Abrar M. Babateen Oliver M. Shannon Gerard M. O’Brien Edward Okello Ellen Smith Dilara Olgacer Christina Koehl William Fostier Emma Wightman David Kennedy John C. Mathers Mario Siervo Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial Nutrients inorganic nitrate beetroot juice cognition cerebral blood flow older adults |
| title | Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial |
| title_full | Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial |
| title_fullStr | Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial |
| title_full_unstemmed | Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial |
| title_short | Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial |
| title_sort | incremental doses of nitrate rich beetroot juice do not modify cognitive function and cerebral blood flow in overweight and obese older adults a 13 week pilot randomised clinical trial |
| topic | inorganic nitrate beetroot juice cognition cerebral blood flow older adults |
| url | https://www.mdpi.com/2072-6643/14/5/1052 |
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