How can aging be reversed? Exploring rejuvenation from a damage‐based perspective
Abstract Advanced age is associated with accumulation of damage and other deleterious changes and a consequential systemic decline of function. This decline affects all organs and systems in an organism, leading to their inadaptability to the environment, and therefore is thought to be inevitable fo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-12-01
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| Series: | Advanced Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ggn2.10025 |
| _version_ | 1811308429562609664 |
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| author | Bohan Zhang Vadim N. Gladyshev |
| author_facet | Bohan Zhang Vadim N. Gladyshev |
| author_sort | Bohan Zhang |
| collection | DOAJ |
| description | Abstract Advanced age is associated with accumulation of damage and other deleterious changes and a consequential systemic decline of function. This decline affects all organs and systems in an organism, leading to their inadaptability to the environment, and therefore is thought to be inevitable for humans and most animal species. However, in vitro and in vivo application of reprogramming strategies, which convert somatic cells to induced pluripotent stem cells, has demonstrated that the aged cells can be rejuvenated. Moreover, the data and theoretical considerations suggest that reversing the biological age of somatic cells (from old to young) and de‐differentiating somatic cells into stem cells represent two distinct processes that take place during rejuvenation, and thus they may be differently targeted. We advance a stemness‐function model to explain these data and discuss a possibility of rejuvenation from the perspective of damage accumulation. In turn, this suggests approaches to achieve rejuvenation of cells in vitro and in vivo. |
| first_indexed | 2024-04-13T09:22:55Z |
| format | Article |
| id | doaj.art-1f921d12692c4a558111967374b18896 |
| institution | Directory Open Access Journal |
| issn | 2641-6573 |
| language | English |
| last_indexed | 2024-04-13T09:22:55Z |
| publishDate | 2020-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Genetics |
| spelling | doaj.art-1f921d12692c4a558111967374b188962022-12-22T02:52:31ZengWileyAdvanced Genetics2641-65732020-12-0111n/an/a10.1002/ggn2.10025How can aging be reversed? Exploring rejuvenation from a damage‐based perspectiveBohan Zhang0Vadim N. Gladyshev1Division of Genetics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USADivision of Genetics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USAAbstract Advanced age is associated with accumulation of damage and other deleterious changes and a consequential systemic decline of function. This decline affects all organs and systems in an organism, leading to their inadaptability to the environment, and therefore is thought to be inevitable for humans and most animal species. However, in vitro and in vivo application of reprogramming strategies, which convert somatic cells to induced pluripotent stem cells, has demonstrated that the aged cells can be rejuvenated. Moreover, the data and theoretical considerations suggest that reversing the biological age of somatic cells (from old to young) and de‐differentiating somatic cells into stem cells represent two distinct processes that take place during rejuvenation, and thus they may be differently targeted. We advance a stemness‐function model to explain these data and discuss a possibility of rejuvenation from the perspective of damage accumulation. In turn, this suggests approaches to achieve rejuvenation of cells in vitro and in vivo.https://doi.org/10.1002/ggn2.10025agingbiomarkers of agingpartial reprogrammingregenerationrejuvenation |
| spellingShingle | Bohan Zhang Vadim N. Gladyshev How can aging be reversed? Exploring rejuvenation from a damage‐based perspective Advanced Genetics aging biomarkers of aging partial reprogramming regeneration rejuvenation |
| title | How can aging be reversed? Exploring rejuvenation from a damage‐based perspective |
| title_full | How can aging be reversed? Exploring rejuvenation from a damage‐based perspective |
| title_fullStr | How can aging be reversed? Exploring rejuvenation from a damage‐based perspective |
| title_full_unstemmed | How can aging be reversed? Exploring rejuvenation from a damage‐based perspective |
| title_short | How can aging be reversed? Exploring rejuvenation from a damage‐based perspective |
| title_sort | how can aging be reversed exploring rejuvenation from a damage based perspective |
| topic | aging biomarkers of aging partial reprogramming regeneration rejuvenation |
| url | https://doi.org/10.1002/ggn2.10025 |
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