Learning multiple variable-speed sequences in striatum via cortical tutoring
Sparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the follo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/26084 |
| _version_ | 1811201001246425088 |
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| author | James M Murray G Sean Escola |
| author_facet | James M Murray G Sean Escola |
| author_sort | James M Murray |
| collection | DOAJ |
| description | Sparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the following key challenges: (i) obtaining control over temporal rescaling of the sequence speed, with the ability to generalize to new speeds; (ii) facilitating flexible expression of distinct sequences via selective activation, concatenation, and recycling of specific subsequences; and (iii) enabling the biologically plausible learning of sequences, consistent with the decoupling of learning and execution suggested by lesion studies showing that cortical circuits are necessary for learning, but that subcortical circuits are sufficient to drive learned behaviors. The same mechanisms that we describe can also be applied to circuits with both excitatory and inhibitory populations, and hence may underlie general features of sequential neural activity pattern generation in the brain. |
| first_indexed | 2024-04-12T02:14:19Z |
| format | Article |
| id | doaj.art-1f933c9ac1be4ce0bd4bf06514b0e95d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:14:19Z |
| publishDate | 2017-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1f933c9ac1be4ce0bd4bf06514b0e95d2022-12-22T03:52:18ZengeLife Sciences Publications LtdeLife2050-084X2017-05-01610.7554/eLife.26084Learning multiple variable-speed sequences in striatum via cortical tutoringJames M Murray0https://orcid.org/0000-0003-3706-4895G Sean Escola1https://orcid.org/0000-0003-0645-1964Center for Theoretical Neuroscience, Columbia University, New York, United StatesCenter for Theoretical Neuroscience, Columbia University, New York, United StatesSparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the following key challenges: (i) obtaining control over temporal rescaling of the sequence speed, with the ability to generalize to new speeds; (ii) facilitating flexible expression of distinct sequences via selective activation, concatenation, and recycling of specific subsequences; and (iii) enabling the biologically plausible learning of sequences, consistent with the decoupling of learning and execution suggested by lesion studies showing that cortical circuits are necessary for learning, but that subcortical circuits are sufficient to drive learned behaviors. The same mechanisms that we describe can also be applied to circuits with both excitatory and inhibitory populations, and hence may underlie general features of sequential neural activity pattern generation in the brain.https://elifesciences.org/articles/26084basal gangliacircuit modelsmotor sequences |
| spellingShingle | James M Murray G Sean Escola Learning multiple variable-speed sequences in striatum via cortical tutoring eLife basal ganglia circuit models motor sequences |
| title | Learning multiple variable-speed sequences in striatum via cortical tutoring |
| title_full | Learning multiple variable-speed sequences in striatum via cortical tutoring |
| title_fullStr | Learning multiple variable-speed sequences in striatum via cortical tutoring |
| title_full_unstemmed | Learning multiple variable-speed sequences in striatum via cortical tutoring |
| title_short | Learning multiple variable-speed sequences in striatum via cortical tutoring |
| title_sort | learning multiple variable speed sequences in striatum via cortical tutoring |
| topic | basal ganglia circuit models motor sequences |
| url | https://elifesciences.org/articles/26084 |
| work_keys_str_mv | AT jamesmmurray learningmultiplevariablespeedsequencesinstriatumviacorticaltutoring AT gseanescola learningmultiplevariablespeedsequencesinstriatumviacorticaltutoring |