<it>Actinobaculum schaalii</it> an emerging pediatric pathogen?
<p>Abstract</p> <p>Background</p> <p><it>Actinobaculum schaalii</it> was first described as a causative agent for human infection in 1997. Since then it has mainly been reported causing urinary tract infections (UTI) in elderly individuals with underlying ur...
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2334/12/201 |
| _version_ | 1818148068342628352 |
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| author | Zimmermann Petra Berlinger Livia Liniger Benjamin Grunt Sebastian Agyeman Philipp Ritz Nicole |
| author_facet | Zimmermann Petra Berlinger Livia Liniger Benjamin Grunt Sebastian Agyeman Philipp Ritz Nicole |
| author_sort | Zimmermann Petra |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Actinobaculum schaalii</it> was first described as a causative agent for human infection in 1997. Since then it has mainly been reported causing urinary tract infections (UTI) in elderly individuals with underlying urological diseases. Isolation and identification is challenging and often needs molecular techniques. <it>A. schaalii</it> is increasingly reported as a cause of infection in humans, however data in children is very limited.</p> <p>Case presentation</p> <p>We present the case of an 8-month-old Caucasian boy suffering from myelomeningocele and neurogenic bladder who presented with a UTI. An ultrasound of the urinary tract was unremarkable. Urinalysis and microscopy showed an elevated leukocyte esterase test, pyuria and a high number of bacteria. Empiric treatment with oral co-trimoxazole was started.</p> <p>Growth of small colonies of Gram-positive rods was observed after 48 h. Sequencing of the 16S rRNA gene confirmed an <it>A. schaalii</it> infection 9 days later. Treatment was changed to oral amoxicillin for 14 days. On follow-up urinalysis was normal and urine cultures were negative.</p> <p>Conclusions</p> <p><it>A.schaalii</it> is an emerging pathogen in adults and children. Colonization and subsequent infection seem to be influenced by the age of the patient. In young children with high suspicion of UTI who use diapers or in children who have known abnormalities of their urogenital tract, infection with <it>A. schaalii</it> should be considered and empiric antimicrobial therapy chosen accordingly.</p> |
| first_indexed | 2024-12-11T12:45:16Z |
| format | Article |
| id | doaj.art-1f93fbdbfb244c31a9546b1749b6384f |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T12:45:16Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-1f93fbdbfb244c31a9546b1749b6384f2022-12-22T01:06:50ZengBMCBMC Infectious Diseases1471-23342012-08-0112120110.1186/1471-2334-12-201<it>Actinobaculum schaalii</it> an emerging pediatric pathogen?Zimmermann PetraBerlinger LiviaLiniger BenjaminGrunt SebastianAgyeman PhilippRitz Nicole<p>Abstract</p> <p>Background</p> <p><it>Actinobaculum schaalii</it> was first described as a causative agent for human infection in 1997. Since then it has mainly been reported causing urinary tract infections (UTI) in elderly individuals with underlying urological diseases. Isolation and identification is challenging and often needs molecular techniques. <it>A. schaalii</it> is increasingly reported as a cause of infection in humans, however data in children is very limited.</p> <p>Case presentation</p> <p>We present the case of an 8-month-old Caucasian boy suffering from myelomeningocele and neurogenic bladder who presented with a UTI. An ultrasound of the urinary tract was unremarkable. Urinalysis and microscopy showed an elevated leukocyte esterase test, pyuria and a high number of bacteria. Empiric treatment with oral co-trimoxazole was started.</p> <p>Growth of small colonies of Gram-positive rods was observed after 48 h. Sequencing of the 16S rRNA gene confirmed an <it>A. schaalii</it> infection 9 days later. Treatment was changed to oral amoxicillin for 14 days. On follow-up urinalysis was normal and urine cultures were negative.</p> <p>Conclusions</p> <p><it>A.schaalii</it> is an emerging pathogen in adults and children. Colonization and subsequent infection seem to be influenced by the age of the patient. In young children with high suspicion of UTI who use diapers or in children who have known abnormalities of their urogenital tract, infection with <it>A. schaalii</it> should be considered and empiric antimicrobial therapy chosen accordingly.</p>http://www.biomedcentral.com/1471-2334/12/201<it>Actinobaculum schaalii</it>ChildrenEmerging infectionUrinary tract infectionGram-positiveAntimicrobial susceptibility |
| spellingShingle | Zimmermann Petra Berlinger Livia Liniger Benjamin Grunt Sebastian Agyeman Philipp Ritz Nicole <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? BMC Infectious Diseases <it>Actinobaculum schaalii</it> Children Emerging infection Urinary tract infection Gram-positive Antimicrobial susceptibility |
| title | <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? |
| title_full | <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? |
| title_fullStr | <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? |
| title_full_unstemmed | <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? |
| title_short | <it>Actinobaculum schaalii</it> an emerging pediatric pathogen? |
| title_sort | it actinobaculum schaalii it an emerging pediatric pathogen |
| topic | <it>Actinobaculum schaalii</it> Children Emerging infection Urinary tract infection Gram-positive Antimicrobial susceptibility |
| url | http://www.biomedcentral.com/1471-2334/12/201 |
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