Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial
Neuromelanin (NM)-sensitive MRI using a magnetization transfer (MT)-prepared T1-weighted sequence has been suggested as a tool to visualize NM contents in the brain. In this study, a new NM-sensitive imaging method, sandwichNM, is proposed by utilizing the incidental MT effects of spatial saturation...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922008278 |
| _version_ | 1811294415536259072 |
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| author | Sooyeon Ji Eun-Jung Choi Beomseok Sohn Kyoungwon Baik Na-Young Shin Won-Jin Moon Seongbeom Park Soohwa Song Phil Hyu Lee Dong Hoon Shin Se-Hong Oh Eung Yeop Kim Jongho Lee |
| author_facet | Sooyeon Ji Eun-Jung Choi Beomseok Sohn Kyoungwon Baik Na-Young Shin Won-Jin Moon Seongbeom Park Soohwa Song Phil Hyu Lee Dong Hoon Shin Se-Hong Oh Eung Yeop Kim Jongho Lee |
| author_sort | Sooyeon Ji |
| collection | DOAJ |
| description | Neuromelanin (NM)-sensitive MRI using a magnetization transfer (MT)-prepared T1-weighted sequence has been suggested as a tool to visualize NM contents in the brain. In this study, a new NM-sensitive imaging method, sandwichNM, is proposed by utilizing the incidental MT effects of spatial saturation RF pulses in order to generate consistent high-quality NM images using product sequences. The spatial saturation pulses are located both superior and inferior to the imaging volume, increasing MT weighting while avoiding asymmetric MT effects. When the parameters of the spatial saturation were optimized, sandwichNM reported a higher NM contrast ratio than those of conventional NM-sensitive imaging methods with matched parameters for comparability with sandwichNM (SandwichNM: 23.6 ± 5.4%; MT-prepared TSE: 20.6 ± 7.4%; MT-prepared GRE: 17.4 ± 6.0%). In a multi-vendor experiment, the sandwichNM images displayed higher means and lower standard deviations of the NM contrast ratio across subjects in all three vendors (SandwichNM vs. MT-prepared GRE; Vendor A: 28.4 ± 1.5% vs. 24.4 ± 2.8%; Vendor B: 27.2 ± 1.0% vs. 13.3 ± 1.3%; Vendor C: 27.3 ± 0.7% vs. 20.1 ± 0.9%). For each subject, the standard deviations of the NM contrast ratio across the vendors were substantially lower in SandwichNM (SandwichNM vs. MT-prepared GRE; subject 1: 1.5% vs. 8.1%, subject 2: 1.1 % vs. 5.1%, subject 3: 0.9% vs. 4.0%, subject 4: 1.1% vs. 5.3%), demonstrating consistent contrasts across the vendors. The proposed method utilizes product sequences, requiring no alteration of a sequence and, therefore, may have a wide practical utility in exploring the NM imaging. |
| first_indexed | 2024-04-13T05:17:12Z |
| format | Article |
| id | doaj.art-1f942bd4e0d44beda45302cba88ad71a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-13T05:17:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-1f942bd4e0d44beda45302cba88ad71a2022-12-22T03:00:52ZengElsevierNeuroImage1095-95722022-12-01264119706Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trialSooyeon Ji0Eun-Jung Choi1Beomseok Sohn2Kyoungwon Baik3Na-Young Shin4Won-Jin Moon5Seongbeom Park6Soohwa Song7Phil Hyu Lee8Dong Hoon Shin9Se-Hong Oh10Eung Yeop Kim11Jongho Lee12Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of KoreaLaboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of KoreaDepartment of Radiology, Severance Hospital, Seoul, Republic of KoreaDepartment of Radiology, Severance Hospital, Seoul, Republic of KoreaDepartment of Radiology, Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiology, Konkuk University Medical Center, Seoul, Republic of KoreaHeuron Co., Ltd., Republic of KoreaHeuron Co., Ltd., Republic of KoreaDepartment of Neurology, Severance Hospital, Seoul, Republic of KoreaHeuron Co., Ltd., Republic of KoreaDivision of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Republic of KoreaDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea; Corresponding authors.Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea; Corresponding authors.Neuromelanin (NM)-sensitive MRI using a magnetization transfer (MT)-prepared T1-weighted sequence has been suggested as a tool to visualize NM contents in the brain. In this study, a new NM-sensitive imaging method, sandwichNM, is proposed by utilizing the incidental MT effects of spatial saturation RF pulses in order to generate consistent high-quality NM images using product sequences. The spatial saturation pulses are located both superior and inferior to the imaging volume, increasing MT weighting while avoiding asymmetric MT effects. When the parameters of the spatial saturation were optimized, sandwichNM reported a higher NM contrast ratio than those of conventional NM-sensitive imaging methods with matched parameters for comparability with sandwichNM (SandwichNM: 23.6 ± 5.4%; MT-prepared TSE: 20.6 ± 7.4%; MT-prepared GRE: 17.4 ± 6.0%). In a multi-vendor experiment, the sandwichNM images displayed higher means and lower standard deviations of the NM contrast ratio across subjects in all three vendors (SandwichNM vs. MT-prepared GRE; Vendor A: 28.4 ± 1.5% vs. 24.4 ± 2.8%; Vendor B: 27.2 ± 1.0% vs. 13.3 ± 1.3%; Vendor C: 27.3 ± 0.7% vs. 20.1 ± 0.9%). For each subject, the standard deviations of the NM contrast ratio across the vendors were substantially lower in SandwichNM (SandwichNM vs. MT-prepared GRE; subject 1: 1.5% vs. 8.1%, subject 2: 1.1 % vs. 5.1%, subject 3: 0.9% vs. 4.0%, subject 4: 1.1% vs. 5.3%), demonstrating consistent contrasts across the vendors. The proposed method utilizes product sequences, requiring no alteration of a sequence and, therefore, may have a wide practical utility in exploring the NM imaging.http://www.sciencedirect.com/science/article/pii/S1053811922008278 |
| spellingShingle | Sooyeon Ji Eun-Jung Choi Beomseok Sohn Kyoungwon Baik Na-Young Shin Won-Jin Moon Seongbeom Park Soohwa Song Phil Hyu Lee Dong Hoon Shin Se-Hong Oh Eung Yeop Kim Jongho Lee Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial NeuroImage |
| title | Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial |
| title_full | Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial |
| title_fullStr | Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial |
| title_full_unstemmed | Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial |
| title_short | Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial |
| title_sort | sandwich spatial saturation for neuromelanin sensitive mri development and multi center trial |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922008278 |
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