Emerging roles of epithelial-mesenchymal transition in hematological malignancies
Abstract Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. H...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12929-018-0440-6 |
| _version_ | 1811279835427766272 |
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| author | San-Chi Chen Tsai-Tsen Liao Muh-Hwa Yang |
| author_facet | San-Chi Chen Tsai-Tsen Liao Muh-Hwa Yang |
| author_sort | San-Chi Chen |
| collection | DOAJ |
| description | Abstract Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma. |
| first_indexed | 2024-04-13T01:02:57Z |
| format | Article |
| id | doaj.art-1f963da3af684fd5bb8e33f92581f7fb |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-13T01:02:57Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-1f963da3af684fd5bb8e33f92581f7fb2022-12-22T03:09:26ZengBMCJournal of Biomedical Science1423-01272018-04-012511810.1186/s12929-018-0440-6Emerging roles of epithelial-mesenchymal transition in hematological malignanciesSan-Chi Chen0Tsai-Tsen Liao1Muh-Hwa Yang2Institute of Clinical Medicine, National Yang-Ming UniversityInstitute of Clinical Medicine, National Yang-Ming UniversityInstitute of Clinical Medicine, National Yang-Ming UniversityAbstract Background Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.http://link.springer.com/article/10.1186/s12929-018-0440-6Epithelial-mesenchymal transitionLeukemiaLymphoma |
| spellingShingle | San-Chi Chen Tsai-Tsen Liao Muh-Hwa Yang Emerging roles of epithelial-mesenchymal transition in hematological malignancies Journal of Biomedical Science Epithelial-mesenchymal transition Leukemia Lymphoma |
| title | Emerging roles of epithelial-mesenchymal transition in hematological malignancies |
| title_full | Emerging roles of epithelial-mesenchymal transition in hematological malignancies |
| title_fullStr | Emerging roles of epithelial-mesenchymal transition in hematological malignancies |
| title_full_unstemmed | Emerging roles of epithelial-mesenchymal transition in hematological malignancies |
| title_short | Emerging roles of epithelial-mesenchymal transition in hematological malignancies |
| title_sort | emerging roles of epithelial mesenchymal transition in hematological malignancies |
| topic | Epithelial-mesenchymal transition Leukemia Lymphoma |
| url | http://link.springer.com/article/10.1186/s12929-018-0440-6 |
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