Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context
The coronavirus disease 2019 (COVID-19) outbreak was first reported December 2019, in Wuhan, China, and has since spread worldwide. Social distancing or isolation measures were taken to mitigate the pandemic. Furthermore, stress and low socioeconomic status in humans confer increased vulnerability t...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354620300685 |
| _version_ | 1818641678205976576 |
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| author | Rodrigo Mattos dos Santos |
| author_facet | Rodrigo Mattos dos Santos |
| author_sort | Rodrigo Mattos dos Santos |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) outbreak was first reported December 2019, in Wuhan, China, and has since spread worldwide. Social distancing or isolation measures were taken to mitigate the pandemic. Furthermore, stress and low socioeconomic status in humans confer increased vulnerability to morbidity and mortality, what can be biologically observed. This condition tends to remain during the Covid-19 pandemic. Social disruption stress (SDR) raises important questions regarding the functioning of the immune system, and the release of several stress hormones. A molecular pattern, conserved transcriptional response to adversity (CTRA), is thought to have evolved to defend against physical injury during periods of heightened risk. Chronic CTRA activation could leave an organism vulnerable to viral infections, leading to increased pro-inflammatory gene expression and a suppression of anti-viral gene expression. The activation of such transcriptional status is related to conditions of social stress through either hostile human contact, or increased predatory vulnerability due to separation from the social group and also low socioeconomic status. This review aims to point out questions for government officials, researchers and health professionals to better target their actions during a pandemic and encourage studies for a better understanding of these characteristics. |
| first_indexed | 2024-12-16T23:30:59Z |
| format | Article |
| id | doaj.art-1f96c37759a644bb823d36afd0693cb7 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-16T23:30:59Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-1f96c37759a644bb823d36afd0693cb72022-12-21T22:11:52ZengElsevierBrain, Behavior, & Immunity - Health2666-35462020-08-017100103Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic contextRodrigo Mattos dos Santos0Department of Tropical Diseases, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Infectious Diseases Laboratory - UNIPEX - FMB UNESP, Rua Dr. Walter Mauricio Correa s/n, São Paulo, BrazilThe coronavirus disease 2019 (COVID-19) outbreak was first reported December 2019, in Wuhan, China, and has since spread worldwide. Social distancing or isolation measures were taken to mitigate the pandemic. Furthermore, stress and low socioeconomic status in humans confer increased vulnerability to morbidity and mortality, what can be biologically observed. This condition tends to remain during the Covid-19 pandemic. Social disruption stress (SDR) raises important questions regarding the functioning of the immune system, and the release of several stress hormones. A molecular pattern, conserved transcriptional response to adversity (CTRA), is thought to have evolved to defend against physical injury during periods of heightened risk. Chronic CTRA activation could leave an organism vulnerable to viral infections, leading to increased pro-inflammatory gene expression and a suppression of anti-viral gene expression. The activation of such transcriptional status is related to conditions of social stress through either hostile human contact, or increased predatory vulnerability due to separation from the social group and also low socioeconomic status. This review aims to point out questions for government officials, researchers and health professionals to better target their actions during a pandemic and encourage studies for a better understanding of these characteristics.http://www.sciencedirect.com/science/article/pii/S2666354620300685Covid-19Conserved transcriptional response to adversity (CTRA)SociogenomicsSocial disruption stressStress hormonesImmune response |
| spellingShingle | Rodrigo Mattos dos Santos Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context Brain, Behavior, & Immunity - Health Covid-19 Conserved transcriptional response to adversity (CTRA) Sociogenomics Social disruption stress Stress hormones Immune response |
| title | Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context |
| title_full | Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context |
| title_fullStr | Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context |
| title_full_unstemmed | Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context |
| title_short | Isolation, social stress, low socioeconomic status and its relationship to immune response in Covid-19 pandemic context |
| title_sort | isolation social stress low socioeconomic status and its relationship to immune response in covid 19 pandemic context |
| topic | Covid-19 Conserved transcriptional response to adversity (CTRA) Sociogenomics Social disruption stress Stress hormones Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2666354620300685 |
| work_keys_str_mv | AT rodrigomattosdossantos isolationsocialstresslowsocioeconomicstatusanditsrelationshiptoimmuneresponseincovid19pandemiccontext |