Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data
In the context of this investigation, we introduce an innovative mathematical model designed to elucidate the intricate dynamics underlying the transmission of Anthroponotic Cutaneous Leishmania. This model offers a comprehensive exploration of the qualitative characteristics associated with the tra...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-01-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2024092?viewType=HTML |
| _version_ | 1797303980503597056 |
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| author | Manal Alqhtani Khaled M. Saad Rahat Zarin Amir Khan |
| author_facet | Manal Alqhtani Khaled M. Saad Rahat Zarin Amir Khan |
| author_sort | Manal Alqhtani |
| collection | DOAJ |
| description | In the context of this investigation, we introduce an innovative mathematical model designed to elucidate the intricate dynamics underlying the transmission of Anthroponotic Cutaneous Leishmania. This model offers a comprehensive exploration of the qualitative characteristics associated with the transmission process. Employing the next-generation method, we deduce the threshold value $ R_0 $ for this model. We rigorously explore both local and global stability conditions in the disease-free scenario, contingent upon $ R_0 $ being less than unity. Furthermore, we elucidate the global stability at the disease-free equilibrium point by leveraging the Castillo-Chavez method. In contrast, at the endemic equilibrium point, we establish conditions for local and global stability, when $ R_0 $ exceeds unity. To achieve global stability at the endemic equilibrium, we employ a geometric approach, a Lyapunov theory extension, incorporating a secondary additive compound matrix. Additionally, we conduct sensitivity analysis to assess the impact of various parameters on the threshold number. Employing center manifold theory, we delve into bifurcation analysis. Estimation of parameter values is carried out using least squares curve fitting techniques. Finally, we present a comprehensive discussion with graphical representation of key parameters in the concluding section of the paper. |
| first_indexed | 2024-03-08T00:02:44Z |
| format | Article |
| id | doaj.art-1f96c401ae7f4ad88b624e853df7464c |
| institution | Directory Open Access Journal |
| issn | 1551-0018 |
| language | English |
| last_indexed | 2024-03-08T00:02:44Z |
| publishDate | 2024-01-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj.art-1f96c401ae7f4ad88b624e853df7464c2024-02-18T01:21:22ZengAIMS PressMathematical Biosciences and Engineering1551-00182024-01-012122084212010.3934/mbe.2024092Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real dataManal Alqhtani0Khaled M. Saad1Rahat Zarin2Amir Khan31. Department of Mathematics, College of Sciences and Arts, Najran University, Najran, Kingdom of Saudi Arabia1. Department of Mathematics, College of Sciences and Arts, Najran University, Najran, Kingdom of Saudi Arabia2. Department of Mathematics, Faculty of Science, King Mongkut's University of Technology, Thonburi (KMUTT), Bangkok 10140, Thailand4. Applied Research Center for Metrology, Standards, and Testing, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia 5. Department of Electrical Engineering, College of Engineering and Physics, King Fahd University for Petroleum and Minerals, Dhahran, Saudi ArabiaIn the context of this investigation, we introduce an innovative mathematical model designed to elucidate the intricate dynamics underlying the transmission of Anthroponotic Cutaneous Leishmania. This model offers a comprehensive exploration of the qualitative characteristics associated with the transmission process. Employing the next-generation method, we deduce the threshold value $ R_0 $ for this model. We rigorously explore both local and global stability conditions in the disease-free scenario, contingent upon $ R_0 $ being less than unity. Furthermore, we elucidate the global stability at the disease-free equilibrium point by leveraging the Castillo-Chavez method. In contrast, at the endemic equilibrium point, we establish conditions for local and global stability, when $ R_0 $ exceeds unity. To achieve global stability at the endemic equilibrium, we employ a geometric approach, a Lyapunov theory extension, incorporating a secondary additive compound matrix. Additionally, we conduct sensitivity analysis to assess the impact of various parameters on the threshold number. Employing center manifold theory, we delve into bifurcation analysis. Estimation of parameter values is carried out using least squares curve fitting techniques. Finally, we present a comprehensive discussion with graphical representation of key parameters in the concluding section of the paper.https://www.aimspress.com/article/doi/10.3934/mbe.2024092?viewType=HTMLgeometric approachcompound matrixstability analysisreal databifurcationsensitivity analysis |
| spellingShingle | Manal Alqhtani Khaled M. Saad Rahat Zarin Amir Khan Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data Mathematical Biosciences and Engineering geometric approach compound matrix stability analysis real data bifurcation sensitivity analysis |
| title | Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data |
| title_full | Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data |
| title_fullStr | Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data |
| title_full_unstemmed | Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data |
| title_short | Qualitative behavior of a highly non-linear Cutaneous Leishmania epidemic model under convex incidence rate with real data |
| title_sort | qualitative behavior of a highly non linear cutaneous leishmania epidemic model under convex incidence rate with real data |
| topic | geometric approach compound matrix stability analysis real data bifurcation sensitivity analysis |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2024092?viewType=HTML |
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