Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis
Chronic obstructive pulmonary disease (COPD) is characterized by respiratory symptoms and non-reversible airflow limitation with recurrent episodes of acute exacerbations. The concurrent presence of bronchiectasis in patients with COPD is associated with reduced respiratory function as well as incre...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/444 |
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| author | Ersilia Nigro Marco Mosella Aurora Daniele Marta Mallardo Mariasofia Accardo Andrea Bianco Fabio Perrotta Filippo Scialò |
| author_facet | Ersilia Nigro Marco Mosella Aurora Daniele Marta Mallardo Mariasofia Accardo Andrea Bianco Fabio Perrotta Filippo Scialò |
| author_sort | Ersilia Nigro |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is characterized by respiratory symptoms and non-reversible airflow limitation with recurrent episodes of acute exacerbations. The concurrent presence of bronchiectasis in patients with COPD is associated with reduced respiratory function as well as increased exacerbation risk. Adiponectin is a promising biomarker in COPD, as greater high molecular weight (HMW) oligomer levels have been observed among COPD patients. Here, we investigate adiponectin levels in two groups of COPD patients characterized by the presence or absence of bronchiectasis (BCO), comparing both groups to healthy controls. We evaluated serum adiponectin levels in COPD patients, those with BCO, and healthy subjects and characterized the pattern of circulating adiponectin oligomers. We found that forced volume capacity % (FVC%) and forced expiratory volume % (FEV1%) were lower for BCO patients than for COPD patients. COPD patients had higher levels of adiponectin and its HMW oligomers than healthy controls. Interestingly, BCO patients had higher levels of adiponectin than COPD patients. We showed that expression levels of IL-2, -4, and -8, IFN-γ, and GM-CSF were significantly higher in BCO patients than in healthy controls. Conversely, IL-10 expression levels were lower in BCO patients. Our data suggest that the increased levels of adiponectin detected in the cohort of BCO patients compared to those in COPD patients without bronchiectasis might be determined by their worse airway inflammatory state. This hypothesis suggests that adiponectin could be considered as a biomarker to recognize advanced COPD patients with bronchiectasis. |
| first_indexed | 2024-03-11T08:32:13Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:13Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-1f97481485b6464abc2ba724cbc9eb072023-11-16T21:41:21ZengMDPI AGLife2075-17292023-02-0113244410.3390/life13020444Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of BronchiectasisErsilia Nigro0Marco Mosella1Aurora Daniele2Marta Mallardo3Mariasofia Accardo4Andrea Bianco5Fabio Perrotta6Filippo Scialò7CEINGE, Biotecnologie Avanzate Scarl, 80145 Napoli, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, ItalyCEINGE, Biotecnologie Avanzate Scarl, 80145 Napoli, ItalyCEINGE, Biotecnologie Avanzate Scarl, 80145 Napoli, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, ItalyDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80138 Naples, ItalyChronic obstructive pulmonary disease (COPD) is characterized by respiratory symptoms and non-reversible airflow limitation with recurrent episodes of acute exacerbations. The concurrent presence of bronchiectasis in patients with COPD is associated with reduced respiratory function as well as increased exacerbation risk. Adiponectin is a promising biomarker in COPD, as greater high molecular weight (HMW) oligomer levels have been observed among COPD patients. Here, we investigate adiponectin levels in two groups of COPD patients characterized by the presence or absence of bronchiectasis (BCO), comparing both groups to healthy controls. We evaluated serum adiponectin levels in COPD patients, those with BCO, and healthy subjects and characterized the pattern of circulating adiponectin oligomers. We found that forced volume capacity % (FVC%) and forced expiratory volume % (FEV1%) were lower for BCO patients than for COPD patients. COPD patients had higher levels of adiponectin and its HMW oligomers than healthy controls. Interestingly, BCO patients had higher levels of adiponectin than COPD patients. We showed that expression levels of IL-2, -4, and -8, IFN-γ, and GM-CSF were significantly higher in BCO patients than in healthy controls. Conversely, IL-10 expression levels were lower in BCO patients. Our data suggest that the increased levels of adiponectin detected in the cohort of BCO patients compared to those in COPD patients without bronchiectasis might be determined by their worse airway inflammatory state. This hypothesis suggests that adiponectin could be considered as a biomarker to recognize advanced COPD patients with bronchiectasis.https://www.mdpi.com/2075-1729/13/2/444adiponectinbiomarkerchronic obstructive pulmonary diseasebronchiectasispro-inflammatory cytokines |
| spellingShingle | Ersilia Nigro Marco Mosella Aurora Daniele Marta Mallardo Mariasofia Accardo Andrea Bianco Fabio Perrotta Filippo Scialò Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis Life adiponectin biomarker chronic obstructive pulmonary disease bronchiectasis pro-inflammatory cytokines |
| title | Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis |
| title_full | Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis |
| title_fullStr | Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis |
| title_full_unstemmed | Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis |
| title_short | Adiponectin Increase in Patients Affected by Chronic Obstructive Pulmonary Disease with Overlap of Bronchiectasis |
| title_sort | adiponectin increase in patients affected by chronic obstructive pulmonary disease with overlap of bronchiectasis |
| topic | adiponectin biomarker chronic obstructive pulmonary disease bronchiectasis pro-inflammatory cytokines |
| url | https://www.mdpi.com/2075-1729/13/2/444 |
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