The prevalence of familial hypercholesterolemia in teenagers from Timișoara
INTRODUCTION FH is one of the most frequent monogenic cholesterol disorders but its prevalence is not very well documented. Variations between 1/200-1/137 individuals have been reported in adult patients. Due to persistent hypercholesterolemia, these patients are exposed to a high risk of deve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Victor Babes University of Medicine and Pharmacy Timisoara
2016-12-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/35/article_35.pdf |
| Summary: | INTRODUCTION
FH is one of the most frequent monogenic
cholesterol disorders but its prevalence is not very well
documented. Variations between 1/200-1/137
individuals have been reported in adult patients. Due to
persistent hypercholesterolemia, these patients are
exposed to a high risk of developing early cardiovascular
disease. Although cardiovascular events usualy occur in
early adulthood, the atherosclerotic prosess
asymtomaticlaly commences in childhood.
OBJECTIVES
study aims to uncover the prevalence of dyslipidemia
in teenagers from Timișoara
MATERIALS AND METHODS
We have conducted an epidemiological study
between March and June 2016 on 318 children aged
between 10-11 years old (4-th grade).We have tested the
lipid profile ( total cholesterol, LDL cholesterol, HDL
cholesterol, triglycerides) from capillary blood using a
point of care LipidoCare Analyzer.
RESULTS
Out of 318 children included in our study 242
(76,1%) had a normal lipid profile, 56 (17,1%) had mild
hypercholesterolemia( LDL cholesterol values ranging
between 130-160 mg/dl), 12 (3,77%) had severe
hypercholesterolemia (LDL cholesterol values were over
160 mg/dl) and 8 (2,51%) children had
hypertriglyceridemia. Out of this group, 2 children
(0,62%-1/159) had LDL cholesterol values over 190
mg/dl, which indicates a high probability of FH.
CONCLUSIONS
The prevalence of dyslipidemia in the studied
group was similar to the scientific data reported in
literature. Although this screeening is the first of it’s kind
in Romania and was conducted on a large group of
subjects, the results cannot be generalized. Further
studies are needed in order to establish the etiology of
dyslipidemia and it’s prevalence in romanian teenagers.
REFERENCES
1.Wiegman A,
,Gidding SS, Watts GF et al.
European Atherosclerosis Society Consensus Panel.
Familial hypercholesterolaemia in children and
adolescents: gaining decades of life by optimizing
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2.Børge G. Nordestgaard, M. John Chapman, Steve
E. Humphries et al. Familial hypercholesterolaemia is
underdiagnosed and undertreated in the general
population: guidance for clinicians to prevent coronary
heart disease. Eur Heart J. doi:
http://dx.doi.org/10.1093/eurheartj/eht273 eht273
3.Alberico LC, Ian G, De Backer G et al. 2016
ESC/EAS Guidelines for the Management of
Dyslipidaemias. European Heart Journal. Volume 37,
Issue 39. p. 2999 - 3058 |
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| ISSN: | 2360-1124 2537-5393 |