Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models

Antitrypanosomal Activity of 1,2,3-Triazole-Based Hybrids Evaluated Using In Vitro Preclinical Translational Models

Chagas disease therapy still relies on two nitroderivatives, nifurtimox and benznidazole (Bz), which have important limitations and serious adverse effects. New therapeutic alternatives for this silent disease, which has become a worldwide public health problem, are essential for its control and eli...

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Bibliographic Details
Main Authors: Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Guilherme Curty Lechuga, Giseli Capaci Rodrigues, Omar Ginoble Pandoli, Druval Santos de Sá, Mirian Claudia de Souza Pereira
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biology
Subjects:
chagas disease
<i>Trypanosoma cruzi</i>
triazole
drug candidates
Online Access:https://www.mdpi.com/2079-7737/12/9/1222

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