An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress

An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress

Abstract Background Adiponectin exerts several beneficial cardiovascular effects, however their specific molecular mechanisms require additional understanding. This study investigated the mechanisms of adiponectin action in the heart during high fat diet (HFD) feeding or in palmitate (PA) treated H9...

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Bibliographic Details
Main Authors: Amy Botta, Ying Liu, Sivaporn Wannaiampikul, Rungsunn Tungtrongchitr, Keith Dadson, Tae-Sik Park, Gary Sweeney
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Nutrition & Metabolism
Subjects:
Adiponectin
Sphingosine-1-phosphate
Ceramide
Cardiomyocyte apoptosis
High fat diet
Palmitate
Online Access:http://link.springer.com/article/10.1186/s12986-019-0342-y

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