Recent advances in the plant epitranscriptome
Abstract Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for mapping RNA modifications and intensive...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-023-02872-6 |
| _version_ | 1797864543991365632 |
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| author | Lisha Shen Jinqi Ma Ping Li Yujin Wu Hao Yu |
| author_facet | Lisha Shen Jinqi Ma Ping Li Yujin Wu Hao Yu |
| author_sort | Lisha Shen |
| collection | DOAJ |
| description | Abstract Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for mapping RNA modifications and intensive characterization of writers, erasers, and readers that deposit, remove, and recognize RNA modifications, respectively. Herein, we review recent advances in characterizing plant epitranscriptome and its regulatory mechanisms in post-transcriptional gene regulation and diverse physiological processes, with main emphasis on N 6-methyladenosine (m6A) and 5-methylcytosine (m5C). We also discuss the potential and challenges for utilization of epitranscriptome editing in crop improvement. |
| first_indexed | 2024-04-09T22:53:36Z |
| format | Article |
| id | doaj.art-1f9a2f075ec74a419ae879dc7c490a8f |
| institution | Directory Open Access Journal |
| issn | 1474-760X |
| language | English |
| last_indexed | 2024-04-09T22:53:36Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj.art-1f9a2f075ec74a419ae879dc7c490a8f2023-03-22T11:22:22ZengBMCGenome Biology1474-760X2023-03-0124112410.1186/s13059-023-02872-6Recent advances in the plant epitranscriptomeLisha Shen0Jinqi Ma1Ping Li2Yujin Wu3Hao Yu4Temasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeAbstract Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for mapping RNA modifications and intensive characterization of writers, erasers, and readers that deposit, remove, and recognize RNA modifications, respectively. Herein, we review recent advances in characterizing plant epitranscriptome and its regulatory mechanisms in post-transcriptional gene regulation and diverse physiological processes, with main emphasis on N 6-methyladenosine (m6A) and 5-methylcytosine (m5C). We also discuss the potential and challenges for utilization of epitranscriptome editing in crop improvement.https://doi.org/10.1186/s13059-023-02872-6 |
| spellingShingle | Lisha Shen Jinqi Ma Ping Li Yujin Wu Hao Yu Recent advances in the plant epitranscriptome Genome Biology |
| title | Recent advances in the plant epitranscriptome |
| title_full | Recent advances in the plant epitranscriptome |
| title_fullStr | Recent advances in the plant epitranscriptome |
| title_full_unstemmed | Recent advances in the plant epitranscriptome |
| title_short | Recent advances in the plant epitranscriptome |
| title_sort | recent advances in the plant epitranscriptome |
| url | https://doi.org/10.1186/s13059-023-02872-6 |
| work_keys_str_mv | AT lishashen recentadvancesintheplantepitranscriptome AT jinqima recentadvancesintheplantepitranscriptome AT pingli recentadvancesintheplantepitranscriptome AT yujinwu recentadvancesintheplantepitranscriptome AT haoyu recentadvancesintheplantepitranscriptome |