Flavonoids in Skin Senescence Prevention and Treatment
Skin aging is associated with the accumulation of senescent cells and is related to many pathological changes, including decreased protection against pathogens, increased susceptibility to irritation, delayed wound healing, and increased cancer susceptibility. Senescent cells secrete a specific set...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6814 |
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| author | Anna Domaszewska-Szostek Monika Puzianowska-Kuźnicka Alina Kuryłowicz |
| author_facet | Anna Domaszewska-Szostek Monika Puzianowska-Kuźnicka Alina Kuryłowicz |
| author_sort | Anna Domaszewska-Szostek |
| collection | DOAJ |
| description | Skin aging is associated with the accumulation of senescent cells and is related to many pathological changes, including decreased protection against pathogens, increased susceptibility to irritation, delayed wound healing, and increased cancer susceptibility. Senescent cells secrete a specific set of pro-inflammatory mediators, referred to as a senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure and function. Thus, drugs that selectively eliminate senescent cells (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There is growing evidence that plant-derived compounds (flavonoids) can slow down or even prevent aging-associated deterioration of skin appearance and function by targeting cellular pathways crucial for regulating cellular senescence and SASP. This review summarizes the senostatic and senolytic potential of flavonoids in the context of preventing skin aging. |
| first_indexed | 2024-03-10T10:04:17Z |
| format | Article |
| id | doaj.art-1f9a5522862f4fbf8b40b548f603f58e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:04:17Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1f9a5522862f4fbf8b40b548f603f58e2023-11-22T01:40:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213681410.3390/ijms22136814Flavonoids in Skin Senescence Prevention and TreatmentAnna Domaszewska-Szostek0Monika Puzianowska-Kuźnicka1Alina Kuryłowicz2Department of Human Epigenetics, Mossakowski Medical Research Centre PAS, 02-106 Warsaw, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS, 02-106 Warsaw, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS, 02-106 Warsaw, PolandSkin aging is associated with the accumulation of senescent cells and is related to many pathological changes, including decreased protection against pathogens, increased susceptibility to irritation, delayed wound healing, and increased cancer susceptibility. Senescent cells secrete a specific set of pro-inflammatory mediators, referred to as a senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure and function. Thus, drugs that selectively eliminate senescent cells (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There is growing evidence that plant-derived compounds (flavonoids) can slow down or even prevent aging-associated deterioration of skin appearance and function by targeting cellular pathways crucial for regulating cellular senescence and SASP. This review summarizes the senostatic and senolytic potential of flavonoids in the context of preventing skin aging.https://www.mdpi.com/1422-0067/22/13/6814senescent cellssenescence-associated secretory phenotype (SASP)flavonoidssenolyticssenostatics |
| spellingShingle | Anna Domaszewska-Szostek Monika Puzianowska-Kuźnicka Alina Kuryłowicz Flavonoids in Skin Senescence Prevention and Treatment International Journal of Molecular Sciences senescent cells senescence-associated secretory phenotype (SASP) flavonoids senolytics senostatics |
| title | Flavonoids in Skin Senescence Prevention and Treatment |
| title_full | Flavonoids in Skin Senescence Prevention and Treatment |
| title_fullStr | Flavonoids in Skin Senescence Prevention and Treatment |
| title_full_unstemmed | Flavonoids in Skin Senescence Prevention and Treatment |
| title_short | Flavonoids in Skin Senescence Prevention and Treatment |
| title_sort | flavonoids in skin senescence prevention and treatment |
| topic | senescent cells senescence-associated secretory phenotype (SASP) flavonoids senolytics senostatics |
| url | https://www.mdpi.com/1422-0067/22/13/6814 |
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